Evidence map›Paper›PMID 39743142›Full record

ArticleMolecules and cells2025

Tumor cells ectopically expressing the membrane-bound form of IL-7 develop an antitumor immune response efficiently in a colon carcinoma model.

Hee-Su Shin, Hyejin Kim, Soon-Gyu Kwon, Hayyoung Lee, Jie-Oh Lee, Young Sang Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hee-Su ShinDepartment of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea.
Hyejin KimDepartment of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea.
Soon-Gyu KwonDepartment of Life Sciences and Institute of Membrane Proteins, POSTECH, Pohang 37673, Korea.
Hayyoung LeeDepartment of Life Sciences and Postech Biotech Center, POSTECH, Pohang 37673, Korea.
Jie-Oh LeeDepartment of Life Sciences and Institute of Membrane Proteins, POSTECH, Pohang 37673, Korea. Electronic address: jieoh@postech.ac.kr.
Young Sang KimDepartment of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Korea. Electronic address: young@cnu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various approaches employing cytokines and cytokine gene-modified tumor cells have been explored to induce antitumor responses, yet their widespread application has been limited due to efficacy concerns and adverse effects. In this study, interleukin-7 was engineered for expression both as a natural secretory form (sIL-7) and as a membrane-bound form fused with the B7.1 type I transmembrane protein (mbIL-7/B7) on CT26 colon cancer cells. Analysis of the resulting cell clones demonstrated that ectopically expressed sIL-7 and mbIL-7/B7 both retained similar capacities to induce the expansion and activation of CD8

Indexed as

Colonic NeoplasmsInterleukin-7AnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMiceMice, Inbred BALB CInterleukin-7Cytokine gene–modified tumor cellsInterleukin-7Membrane-bound formTumor cell vaccineTumor therapy

Identifiers

PMID39743142
PMCPMC11873615

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.