Evidence map›Paper›PMID 39742913›Full record

Trial reportChest2025

Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes: A Randomized Controlled Trial.

Sheng-Yuan Ruan, Yao-Wen Kuo, Chun-Ta Huang, Ying-Chun Chien, Chun-Kai Huang, Lu-Cheng Kuo, Jerry Shu-Hung Kuo, Kuei-Pin Chung, Shih-Chi Ku, Jung-Yien Chien and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04934163 (Effect of Flow Rates of Postextubation High-flow Nasal Cannula on Extubation Outcome), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04934163 nacompletednot on this map

Effect of Flow Rates of Postextubation High-flow Nasal Cannula on Extubation Outcome: An Open-label, Randomized Controlled Trial

TypeinterventionalSponsorNational Taiwan University HospitalRan2021 to 2023Enrolled180ConditionsHypoxemic Respiratory FailureArmsFlow rate setting of high-flow nasal cannula (initially 60L/min), Flow rate setting of high-flow nasal cannula (initially 40L/min)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sheng-Yuan RuanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
Yao-Wen KuoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan; Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, Taipei, Taiwan.
Chun-Ta HuangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
Ying-Chun ChienDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
Chun-Kai HuangDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
Lu-Cheng KuoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
Jerry Shu-Hung KuoDepartment of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin County, Taiwan.
Kuei-Pin ChungDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Shih-Chi KuDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan.
Jung-Yien ChienDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine National Taiwan University, Taipei, Taiwan. Electronic address: jychien@ntu.edu.tw.
Taiwan Collaborative Intensive Care Study (TACTICS) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-flow nasal cannula (HFNC) has emerged as a promising intervention for postextubation oxygen therapy, with the potential to reduce the need for reintubation. However, it remains unclear whether using a higher flow setting provides better outcomes than the commonly used flow rate of 30 to 50 L/min. RESEARCH QUESTION: Does setting the flow rate of HFNC at 60 L/min vs 40 L/min for postextubation care result in different extubation outcomes? STUDY DESIGN AND

methodsThis randomized controlled trial assigned intubated patients to receive HFNC at either a 60 L/min or 40 L/min flow rate following extubation. The assigned flow rate was maintained for 24 hours. The primary outcome was a composite of reintubation or the use of noninvasive ventilation (NIV) within 48 hours' after extubation. Key secondary outcomes included ahead-of-schedule changes in HFNC settings and mortality.

resultsA total of 180 patients were randomized; 169 were included in the analysis (86 in the 40 L/min group and 83 in the 60 L/min group). The primary outcome events occurred in 19 patients (22.1%) in the 40 L/min group and in 14 patients (16.9%) in the 60 L/min group (risk difference, 5.2%; 95% CI, -6.7% to 17.1%; P = .39). For secondary outcomes, the 40 L/min group was associated with a higher risk of escalation in respiratory support, defined as using NIV or up-titration of HFNC settings (24 [27.9%] vs 8 [9.6%]; P = .002).

interpretationIn unselected extubated patients, setting the HFNC flow rate at 60 L/min did not reduce the risk of reintubation or NIV use compared with a flow rate of 40 L/min. Using a flow rate of 40 L/min with as-needed up-titration may be a reasonable alternative to setting the flow at 60 L/min for postextubation care. However, this trial may not have been sufficiently powered to exclude a small between-group difference. CLINICAL

trial registrationClinicalTrials.gov; No.: NCT04934163; URL: www. CLINICALTRIALS: gov.

Indexed as

Airway ExtubationCannulaNoninvasive VentilationOxygen Inhalation TherapyAgedFemaleHumansIntubation, IntratrachealMaleMiddle AgedTreatment Outcomeextubationhigh-flow nasal cannulahigh-flow oxygen therapyreintubationrespiratory failure

Identifiers

PMID39742913
PMCPMC12106955

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.