Evidence map›Paper›PMID 39742814›Full record

ArticleJournal of electrocardiology

12 lead surface ECGs as a surrogate of atrial electrical remodeling - a deep learning based approach.

Ishan Vatsaraj, Yazan Mohsen, Lukas Grüne, Lucas Steffens, Shane Loeffler, Marc Horlitz, Florian Stöckigt, Natalia Trayanova

Abstract read
In one paragraph

Article in Journal of electrocardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ishan VatsarajDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA. Electronic address: ivatsar1@jhu.edu.
Yazan MohsenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA; Department of Cardiology, Faculty of Health, School of Medicine, University Witten/Herdecke, Witten, Germany; Krankenhaus Porz am Rhein, Department of Cardiology, Electrophysiology and Rhythmology, Cologne, Germany.
Lukas GrüneKrankenhaus Porz am Rhein, Department of Cardiology, Electrophysiology and Rhythmology, Cologne, Germany.
Lucas SteffensKrankenhaus Porz am Rhein, Department of Cardiology, Electrophysiology and Rhythmology, Cologne, Germany.
Shane LoefflerDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA.
Marc HorlitzDepartment of Cardiology, Faculty of Health, School of Medicine, University Witten/Herdecke, Witten, Germany; Krankenhaus Porz am Rhein, Department of Cardiology, Electrophysiology and Rhythmology, Cologne, Germany.
Florian StöckigtKrankenhaus Porz am Rhein, Department of Cardiology, Electrophysiology and Rhythmology, Cologne, Germany; Department of Cardiology, University Hospital Bonn, Bonn, Germany.
Natalia TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, MD, USA.

Funding

Artificial intelligence analysis of atrial remodeling evolution in patients with atrial fibrillation: Towards optimal ablation strategiesR01HL166759 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Eugene Kholmovski, David Spragg · 2023 to 2026
$3.2M
Heart Digital Twin Analysis of Arrhythmias due to Infiltrating AdiposityR01HL174440 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI NATALIA A. TRAYANOVA · 2024 to 2026
$2.1M
NHLBI NIH HHS R01 HL166759NHLBI NIH HHS R01 HL174440
6 · The paper itself

Abstract

background and purposeAtrial fibrillation (AF), a common arrhythmia, is linked with atrial electrical and structural changes, notably low voltage areas (LVAs) which are associated with poor ablation outcomes and increased thromboembolic risk. This study aims to evaluate the efficacy of a deep learning model applied to 12‑lead ECGs for non-invasively predicting the presence of LVAs, potentially guiding pre-ablation strategies and improving patient outcomes.

methodsA retrospective analysis was conducted on 204 AF patients, who underwent catheter ablation. Pre-procedural sinus rhythm ECGs and electroanatomical maps (EAM) were utilized alongside demographic data to train a deep learning model combining Long Short-Term Memory networks and Convolutional Neural Networks with a cross-attention layer. Model performance was evaluated using a 5-fold cross-validation strategy.

resultsThe model effectively identified the presence of LVA on the examined atrial walls, achieving accuracies of 78 % for both the anterior and posterior walls, and 82 % for the LA roof. Moreover, it accurately predicted the global left atrial (LA) average voltage <0.7 mV, with an accuracy of 88 %.

conclusionThe study showcases the potential of deep learning applied to 12‑lead ECGs to effectively predict regional LVAs and global LA voltage in AF patients non-invasively. This model offers a promising tool for the pre-ablation assessment of atrial substrate, facilitating personalized therapeutic strategies and potentially enhancing ablation success rates.

Indexed as

Atrial FibrillationAtrial RemodelingDeep LearningElectrocardiographyAgedCatheter AblationFemaleHeart AtriaHumansMaleMiddle AgedRetrospective StudiesAtrial fibrillationDeep learningECGLow voltage areasPredictive modeling

Identifiers

PMID39742814
PMCPMC11929969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.