ArticleThe Journal of surgical research2025
Predicting Unilateral Aldosterone Secretion in Primary Aldosteronism.
Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionPrimary aldosteronism affects 20% of patients with resistant hypertension and may be due to unilateral or bilateral causes. Patients with a unilateral source of aldosterone secretion are potentially curable with adrenalectomy. Adrenal vein sampling (AVS) is the definitive test for subtype differentiation but may not be accessible outside tertiary centers. The goal of this study was to determine whether clinical characteristics can predict a unilateral source of aldosterone on AVS.
methodsPatients with a biochemical diagnosis of primary aldosteronism who underwent AVS between 1998 and 2019 were identified from a prospectively maintained database. Unilateral aldosterone secretion was defined as lateralization index ≥4. Univariate and multivariate logistic regression were used to assess the correlation between clinical characteristics and unilateral aldosterone secretion. A risk score was developed to predict a unilateral source of aldosterone.
resultsOf 461 patients, 61% were male and 39% female. The mean age was 54 ± 11 y, and median duration of hypertension was 10 (interquartile range: 5-20) y. A total of 324 patients had unilateral aldosterone secretion. On multivariate logistic regression analysis, non-Black race, lower body mass index, shorter duration of hypertension, and nonincidental diagnoses were significantly associated with a unilateral source of aldosterone. Neither age nor an adrenal adenoma on imaging was predictive of a unilateral aldosterone source. The clinical risk score had an 86% positive predictive value for a unilateral source of aldosterone.
conclusionsClinical characteristics imperfectly predict subtype differentiation. However, high clinical risk scores have a strong positive predictive value for a unilateral source of aldosterone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.