Evidence map›Paper›PMID 39742503›Full record

ArticleScience translational medicine2025

Lipidomic profiling of mouse brain and human neuron cultures reveals a role for

Isaac Tang, Ashna Nisal, Alex Reed, Timothy B Ware, Anide Johansen, Maha S Zaki, Benjamin F Cravatt, Joseph G Gleeson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Longitudinal Characterization of GiantResearch (Washington, D.C.) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isaac TangRady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA.ORCID 0000-0003-3028-6786
Ashna NisalRady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA.ORCID 0009-0000-4384-1027
Alex ReedDepartment of Chemistry, Scripps Research, La Jolla, CA 92037, USA.
Timothy B WareDepartment of Chemistry, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0002-2870-7812
Anide JohansenRady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA.
Maha S ZakiClinical Genetics Department, Human Genetics and Genome Research Institute, National Research Centre, Cairo 12311, Egypt.ORCID 0000-0001-7840-0002
Benjamin F CravattDepartment of Chemistry, Scripps Research, La Jolla, CA 92037, USA.ORCID 0000-0001-5330-3492
Joseph G GleesonRady Children's Institute for Genomic Medicine, San Diego, CA 92123, USA.ORCID 0000-0002-0889-9220

Funding

Molecular Characterization of Pontocerebellar HypoplasiaR01NS098004 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOSEPH G GLEESON · 2016 to 2026
$4.6M
NINDS NIH HHS R01 NS098004
6 · The paper itself

Abstract

Mutations in lipid regulator genes are a frequent cause of autism spectrum disorder, including those regulating phosphatidylinositol (PI) and phosphoinositide 3-kinase signaling.

Indexed as

AcyltransferasesBrainCell MovementLipidomicsMice, KnockoutNeuronsSignal TransductionTOR Serine-Threonine KinasesAnimalsCells, CulturedHumansMembrane ProteinsMicePhosphatidylinositolsAcyltransferasesMBOAT7 protein, humanMembrane ProteinsPhosphatidylinositolsTOR Serine-Threonine Kinases

Identifiers

PMID39742503
PMCPMC13050510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.