Evidence map›Paper›PMID 39742494›Full record

ArticleScience advances2025

Large language models for human-machine collaborative particle accelerator tuning through natural language.

Jan Kaiser, Anne Lauscher, Annika Eichler

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jan KaiserDeutsches Elektronen-Synchrotron DESY, Hamburg, Germany.ORCID 0000-0003-3445-0678
Anne LauscherUniversität Hamburg, Hamburg, Germany.ORCID 0000-0001-8590-9827
Annika EichlerDeutsches Elektronen-Synchrotron DESY, Hamburg, Germany.ORCID 0000-0003-3282-3135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autonomous tuning of particle accelerators is an active and challenging research field with the goal of enabling advanced accelerator technologies and cutting-edge high-impact applications, such as physics discovery, cancer research, and material sciences. A challenge with autonomous accelerator tuning remains that the most capable algorithms require experts in optimization and machine learning to implement them for every new tuning task. Here, we propose the use of large language models (LLMs) to tune particle accelerators. We demonstrate on a proof-of-principle example the ability of LLMs to tune an accelerator subsystem based on only a natural language prompt from the operator, and compare their performance to state-of-the-art optimization algorithms, such as Bayesian optimization and reinforcement learning-trained optimization. In doing so, we also show how LLMs can perform numerical optimization of a nonlinear real-world objective. Ultimately, this work represents another complex task that LLMs can solve and promises to help accelerate the deployment of autonomous tuning algorithms to day-to-day particle accelerator operations.

Identifiers

PMID39742494
PMCPMC11691695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.