ArticleScience advances2025
High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
–field-weighted citation impact
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Who cites it
28 citing papers in PubMed.
- Early mucosal responses following a randomised controlled human inhaled infection with attenuated Mycobacterium bovis BCG.Nature communications · 2025Trial
- Mucosal BCG Vaccination and Immune Layering: Route-Dependent Programming of Immunity at the Respiratory Interface.Vaccines · 2026Review
- The host immune response to Mycobacterium tuberculosis determining protection or disease progression.Nature immunology · 2026Review
- Immunological mechanistic action of intravenous BCG-mediated protection against tuberculosis.Cellular and molecular life sciences : CMLS · 2026Review
- Context-specific roles for IL-17 in tuberculosis.PLoS pathogens · 2026Review
- Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis.PLoS pathogens · 2026Article
- BCG vaccination induces antibacterial effector functions among Vδ1/3 T cells that are associated with protection against tuberculosis.Cell reports. Medicine · 2026Article
- The BCGMethodsX · 2025Article
- BCG Vaccine-Induced Innate and Adaptive Pulmonary Immunity Correlating with Protective Efficacy AgainstVaccines · 2025Article
- Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases.Life medicine · 2025Review
- Deconvoluting the interplay of innate and adaptive immunity in BCG-induced nonspecific and TB-specific host resistance.The Journal of experimental medicine · 2025Review
- Intravenous BCG-mediated protection against tuberculosis requires CD4+ T cells and CD8α+ lymphocytes.The Journal of experimental medicine · 2025Article
- Experimental dissection of tuberculosis protective immunity: a human perspective.Frontiers in cellular and infection microbiology · 2025Review
- Humoral correlates of protection againstiScience · 2024Article
- Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques.Cell systems · 2024Article
- Intranasal vaccination with engineered BCG expressing CCL2 induces a stronger immune barrier against Mycobacterium tuberculosis than BCG.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Intravenous Bacillus Calmette-Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus-infected Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Single-cell sequencing: Current applications in various tuberculosis specimen types.Cell proliferation · 2024Review
- Markov Field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
19 authors.
Joshua M PetersDepartment of Biological Engineering, MIT, Cambridge, MA, USA.ORCID 0000-0001-9163-6706
Edward B IrvineRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.
Mohau S MakatsaDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Jacob M RosenbergRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.
Marc H WadsworthRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.ORCID 0000-0001-9479-8516
Travis K HughesRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.
Matthew S SuttonVaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID 0009-0002-4133-3293
Sarah K NyquistRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.ORCID 0000-0002-9045-3665
Joshua D BromleyRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.ORCID 0000-0001-8692-2740
Rajib MondalResearch Laboratory of Electronics, Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.ORCID 0000-0002-9531-9852
Mario RoedererVaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0001-7448-7040
Robert A SederVaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-3133-0849
Patricia A DarrahVaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-0035-2802
Galit AlterRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.ORCID 0000-0002-9221-6735
Chetan SeshadriDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
JoAnne L FlynnDepartment of Microbiology and Molecular Genetics and Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0001-7874-8981
Alex K ShalekRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.ORCID 0000-0001-5670-8778
Sarah M FortuneRagon Institute of MGH, Harvard, and MIT, Cambridge, MA, USA.ORCID 0000-0001-7565-9975
Bryan D BrysonDepartment of Biological Engineering, MIT, Cambridge, MA, USA.ORCID 0000-0003-1716-6712
Funding
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4MIMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)75N93019C00071 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI FORTUNE, SARAH · 2019 to 2025
$57.3MInstitutional Career Development CoreKL2TR002542 · NCATS · HARVARD MEDICAL SCHOOL · PI BREDELLA, MIRIAM ANTOINETTE, RUTKOVE, SEWARD B. · 2018 to 2022
$8.7MGraduate Training in Computational and Systems BiologyT32GM087237 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BURGE, CHRISTOPHER B · 2009 to 2023
$4.6MAn integrated multiplexed genomic assay for low input clinical samples1U24AI118672 · NIAID · BROAD INSTITUTE, INC. · PI SHALEK, ALEX K · 2015 to 2019
$2.0MExploiting Fc-engineering to dissect mechanisms of anti-microbial action of M. tuberculosis-specific antibodiesF31AI150171 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI IRVINE, EDWARD BUFORD · 2020 to 2021
$64kNCATS NIH HHS KL2 TR002542NIAID NIH HHS 75N93019C00071NIAID NIH HHS F31 AI150171NIAID NIH HHS P30 AI060354NIAID NIH HHS U24 AI118672NIGMS NIH HHS T32 GM087237
Abstract
Intradermal Bacillus Calmette-Guérin (BCG) is the most widely administered vaccine, but it does not sufficiently protect adults against pulmonary tuberculosis. Recent studies in nonhuman primates show that intravenous BCG administration offers superior protection against
Indexed as
BCG VaccineMacaca mulattaSignal TransductionVaccinationAdministration, IntravenousAnimalsBronchoalveolar Lavage FluidMacrophages, AlveolarMycobacterium tuberculosisTuberculosis, PulmonaryBCG Vaccine
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.