Evidence map›Paper›PMID 39742339›Full record

ArticleJournal of molecular and cellular cardiology plus2024

Modeling immune checkpoint inhibitor associated myocarditis

Garrett Jensen, Xinjie Wang, Jacob Kuempel, Zhishi Chen, Wei Yu, Nicolas Palaskas, Mary Sobieski, Nghi Nguyen, Reid T Powell, Clifford Stephan and 2 more

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Immune checkpoint inhibitor-associated myocarditis: a historical and comprehensive review.American journal of physiology. Heart and circulatory physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Garrett JensenTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Xinjie WangTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Jacob KuempelTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Zhishi ChenTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Wei YuTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Nicolas PalaskasThe MD Anderson Cancer Center Department of Cardiology, United States of America.
Mary SobieskiTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Nghi NguyenTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Reid T PowellTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Clifford StephanTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Weijia LuoTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.
Jiang ChangTexas A&M College of Medicine Institute for Biosciences and Technology, Houston, TX, United States of America.

Funding

Epigenetic signaling, pathological cardiac hypertrophy and Western dietR01HL148133 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2020 to 2023
$2.2M
Epigenomic signaling and heart failure.R01HL150124 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2020 to 2023
$2.1M
RhoE-mediated Sterile Inflammation Regulation in Acute Myocardial Infarction.R01HL141215 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2018 to 2021
$1.5M
Profiling communication networks of endogenous exosomesR21HL157708 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CHANG, JIANG · 2021 to 2022
$417k
NHLBI NIH HHS R01 HL141215NHLBI NIH HHS R01 HL148133NHLBI NIH HHS R01 HL150124NHLBI NIH HHS R21 HL157708
6 · The paper itself

Abstract

Immune checkpoint inhibitor-associated myocarditis is the most lethal side effect of immune checkpoint blockade. Myocarditis leads to persistently increased mortality and lacks effective treatments. The development of patient-relevant disease models may enable disease prediction, increased understanding of disease pathophysiology, and the development of effective treatment strategies. Here, we report a new method to model immune checkpoint inhibitor-associated myocarditis

Indexed as

CardiomyocytesHuman induced pluripotent stem cellsImmune checkpoint inhibitorsModelingMyocarditisPersonalized medicine

Identifiers

PMID39742339
PMCPMC11687339

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.