ArticleiMeta2024
Bioprospecting of culturable marine biofilm bacteria for novel antimicrobial peptides.
Article in iMeta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ManagingMolecules (Basel, Switzerland) · 2025Pooled it
- A N-methylated antimicrobial peptide targets the fructose transporter FruA of Staphylococcus aureus.The Journal of antibiotics · 2026Article
- Multisite Colonization Ecology of Multidrug-Resistant and Commensal Bacteria Among Cardiovascular Outpatients: A Cross-Sectional Study from Cairo, Egypt.Antibiotics (Basel, Switzerland) · 2026Article
- Metagenomic screening of antimicrobial peptide candidates and isolation of two active peptides from bat gut bacteria.World journal of microbiology & biotechnology · 2026Article
- Siderophore sharing protects clonalApplied and environmental microbiology · 2026Article
- Genomic and chemical analyses of 713 marine biofilm-derived bacterial strains.Applied and environmental microbiology · 2026Article
- Mobile Genetic Elements as Central Drivers of Antimicrobial Resistance: Molecular Mechanisms, Evolutionary Ecology, One Health Implications and Control Strategies.Antibiotics (Basel, Switzerland) · 2026Review
- Unlocking the unexplored AMPSphere in marine rare species.Microbiome · 2026Article
- Article
- Marine Antimicrobial Peptides: Advances in Discovery, Multifunctional Mechanisms, and Therapeutic Translation Challenges.Marine drugs · 2025Review
- A novel generative framework for designing pathogen-targeted antimicrobial peptides with programmable physicochemical properties.PLoS computational biology · 2025Article
- Gram-Negative Microbiota Derived from Trout Fished in Slovakian Water Sources and Their Relationship to Postbiotics.Pathogens (Basel, Switzerland) · 2025Article
- Antibacterial and Anti-Adherence Efficacy of Silver Nanoparticles Against Endodontic Biofilms: An In Vitro and Ex Vivo Study.Pharmaceutics · 2025Article
- Host-Associated Biofilms:Microorganisms · 2025Review
- Synthesis and Evaluation of Aquatic Antimicrobial Peptides Derived from Marine Metagenomes Using a High-Throughput Screening Approach.Marine drugs · 2025Article
- Branched-chain amino acid metabolism supports Roseobacteraceae positive interactions in marine biofilms.Applied and environmental microbiology · 2025Article
- Article
- Genomic Features and Antimicrobial Activity ofMarine drugs · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs) have become a viable source of novel antibiotics that are effective against human pathogenic bacteria. In this study, we construct a bank of culturable marine biofilm bacteria constituting 713 strains and their nearly complete genomes and predict AMPs using ribosome profiling and deep learning. Compared with previous approaches, ribosome profiling has improved the identification and validation of small open reading frames (sORFs) for AMP prediction. Among the 80,430 expressed sORFs, 341 are identified as candidate AMPs with high probability. Most potential AMPs have less than 40% similarity in their amino acid sequence compared to those listed in public databases. Furthermore, these AMPs are associated with bacterial groups that are not previously known to produce AMPs. Therefore, our deep learning model has acquired characteristics of unfamiliar AMPs. Chemical synthesis of 60 potential AMP sequences yields 54 compounds with antimicrobial activity, including potent inhibitory effects on various drug-resistant human pathogens. This study extends the range of AMP compounds by investigating marine biofilm microbiomes using a novel approach, accelerating AMP discovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.