ArticleiMeta2024
Comprehensive multi-tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding.
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Who cites it
20 citing papers in PubMed.
- Article
- Bridging precision agriculture and human medicine through comparative genetics.Nature reviews. Genetics · 2026Review
- Integrated ATAC-Seq and RNA-Seq Reveal Candidate Regulatory Genes and Chromatin Accessibility Associated with Intramuscular Fat Deposition: An Animal Trial in Hezuo Pigs.Animals : an open access journal from MDPI · 2026Article
- Multi-Omics Epigenetic Landscape Unveils Regulatory Mechanisms Underlying Heterosis in Sheep Muscle Development.Animals : an open access journal from MDPI · 2026Article
- Identification of cis-regulatory elements provides insights into tissue-specific gene regulation in the sheep genome.Nature communications · 2026Article
- Epigenetic Regulation of Production Traits in Ruminants: Implications for Breeding and Selection.Biology · 2026Review
- Integrative analysis of rumen microbiota and host multi-organ interactions underlying feed conversion efficiency in Hu sheep.Journal of animal science and biotechnology · 2026Article
- Article
- Single-cell atlas reveals cellular heterogeneity and BMP5-mediated regulation of adipogenic differentiation in sheep adipose tissue.Communications biology · 2026Article
- Multi-omics profiling of chromatin accessibility and H3K27ac reveals super-enhancer-mediated regulatory networks governing endometrial receptivity in goats.Journal of animal science and biotechnology · 2026Article
- Whole-Genome Resequencing Identifies Candidate Genes for Tail Fat Deposition in Sheep.Animals : an open access journal from MDPI · 2025Article
- Expression of LGALS3 and XPNPEP2 genes and their association with growth traits in sheep.Tropical animal health and production · 2025Article
- Host Genetic Effects and Phenotypic Landscapes of Rumen Bacterial Enterotypes in a Large Sheep Population.Animals : an open access journal from MDPI · 2025Article
- Conservation of Domestic Animal Genetic Resources in China: Overview of the Status, Activities, Policies, and Challenges.Life (Basel, Switzerland) · 2025Review
- A Functional Regulatory Variant ofAnimals : an open access journal from MDPI · 2025Article
- Potential Epigenetic Impacts of Phytochemicals on Ruminant Health and Production: Connecting Lines of Evidence.Animals : an open access journal from MDPI · 2025Review
- Genetic and Epigenetic Adaptation Mechanisms of Sheep Under Multi-Environmental Stress Environment.International journal of molecular sciences · 2025Review
- Whole-Genome Resequencing in Sheep: Applications in Breeding, Evolution, and Conservation.Genes · 2025Review
- Regulatory element map of sheep reproductive tissues: functional annotation of tissue-specific strong active enhancers.Frontiers in veterinary science · 2025Article
- Article
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Authors and funding
29 authors.
Deyin ZhangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.ORCID 0000-0001-9587-084X
Jiangbo ChengState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Xiaolong LiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Kai HuangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Lvfeng YuanLanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences (CAAS) Lanzhou China.
Yuan ZhaoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Dan XuCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Yukun ZhangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Liming ZhaoState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Xiaobin YangCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Zongwu MaCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Quanzhong XuState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Chong LiCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Xiaojuan WangCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Chen ZhengCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Defu TangCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Fang NianCollege of Science Gansu Agricultural University Lanzhou China.
Xiangpeng YueState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Wanhong LiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Huibin TianState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Xiuxiu WengState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Peng HuKey Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education Shanghai Ocean University Shanghai China.
Yuanqing FengDepartment of Genetics University of Pennsylvania Philadelphia PA USA.
Peter KaldsYazhouwan National Laboratory Sanya China.
Zhihua JiangDepartment of Animal Sciences and Center for Reproductive Biology Washington State University (WSU) Pullman WA USA.
Yunxia ZhaoKey Laboratory of Agricultural Animal Genetics, Breeding, and Reproduction of the Ministry of Education Huazhong Agricultural University Wuhan China.ORCID 0000-0002-2253-2484
Xiaoxue ZhangCollege of Animal Science and Technology Gansu Agricultural University Lanzhou China.
Fadi LiState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Weimin WangState Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems; Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Afairs; Engineering Research Center of Grassland Industry, Ministry of Education; College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic functional annotation of the sheep genome is lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome data from 2357 individuals across 29 breeds worldwide, and 4006 phenotypic data related to tail fat weight. We constructed the first multi-tissue epigenome atlas in terms of functional elements, chromatin states, and their functions and explored the utility of the functional elements in interpreting phenotypic variation during sheep domestication and improvement. Particularly, we identified a total of 753,723 nonredundant functional elements, with over 60% being novel. We found tissue-specific promoters and enhancers related to sensory abilities and immune response that were highly enriched in genomic regions influenced by domestication, while
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BMP2epigenomicsgenome‐wide association studiesmulti‐omicsregulatory elementssheep
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