Evidence map›Paper›PMID 39742246›Full record

ArticleReviews in cardiovascular medicine2024

Characterizing Vericiguat Treatment in Heart Failure: A Multicenter Real-World Study in China.

Qi Wang, Guangchuan Wang, Jiecheng Peng, Jingjing Li, Changlin Ju, Lingxin Pan, Zhiwei Xu, Jun Qian, Zhiquan Liu, Guohong Wu and 5 more

Abstract read
In one paragraph

Article in Reviews in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qi WangDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.ORCID https://orcid.org/0000-0002-2186-8496
Guangchuan WangDepartment of Cardiology, Huaibei People's Hospital, 235000 Huaibei, Anhui, China.
Jiecheng PengDepartment of Cardiology, The First People's Hospital of Anqing Affiliated to Anhui Medical University, 246004 Anqing, Anhui, China.
Jingjing LiDepartment of Cardiology, The Third People's Hospital of Bengbu, 233000 Bengbu, Anhui, China.
Changlin JuDepartment of Cardiology, The First Affiliated Hospital of Wannan Medical College, 241001 Wuhu, Anhui, China.
Lingxin PanDepartment of Cardiology, People's Hospital of Tongling, 244000 Tongling, Anhui, China.
Zhiwei XuDepartment of Cardiology, Anhui No.2 Provincial People's Hospital, 230041 Hefei, Anhui, China.
Jun QianDepartment of Cardiology, Maanshan General Hospital of Ranger-Duree Healthcare, 243071 Maanshan, Anhui, China.
Zhiquan LiuDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.
Guohong WuDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.
Xueping WeiDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.
Ji YanDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.
Xuejun XiangDepartment of Cardiology, Anqing Municipal Hospital, 246004 Anqing, Anhui, China.
Kangyu ChenDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, China.ORCID https://orcid.org/0000-0002-7095-6767
HCDCG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Real-world data on the clinical benefit of vericiguat are currently limited. This multicenter, real-world study was conducted to evaluate the clinical characteristics and therapeutic effects of vericiguat in real-world settings. Methods: This study analyzed heart failure (HF) patients who initiated vericiguat treatment from September 2022 to August 2023 across nine hospitals in the Anhui Province, China. The clinical data were retrospectively collected and cases were prospectively followed to assess changes from baseline in N-terminal pro-B type natriuretic peptide (NT-proBNP) at 12 months. Baseline characteristics were compared with those in the VICTORIA trial. Results: Of the 285 patients enrolled, the mean age was 64.8 ± 12.9 years. Of these, 22.8% were female, and 94.7% were classified as New York Heart Association class III-IV. Additionally, 66.4% had a reduced ejection fraction with a median NT-proBNP level of 2915 pg/mL. Vericiguat therapy was initiated during hospitalization in 223 patients (78.2%), with 105 (37.1%) receiving quadruple anti-HF therapy. Only 44.9% met the VICTORIA trial inclusion criteria. Conclusions: In this multicenter, real-world study of vericiguat in Anhui Province, only 44.9% of vericiguat users met the inclusion criteria for the VICTORIA trial. This suggests that vericiguat is being applied more broadly by physicians to treat HF in real clinical settings.

Indexed as

heart failurereal-world studyvericiguat

Identifiers

PMID39742246
PMCPMC11683721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.