Evidence map›Paper›PMID 39742213›Full record

ArticleACG case reports journal2025

Atorvastatin-Induced Liver Injury With Concurrent Rhabdomyolysis After a Positive Rechallenge.

Harjit Singh, Adam Khalaf, Bryce F Kunkle, Sherry Gholami, James H Lewis, Amol S Rangnekar

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ACG case reports journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harjit SinghDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC.
Adam KhalafDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC.
Bryce F KunkleDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC.
Sherry GholamiDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC.
James H LewisDepartment of Gastroenterology and Hepatology, Medstar Georgetown University Hospital, Washington, DC.
Amol S RangnekarMedstar Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Statin-induced liver injury has been widely described. However, cases of clinically significant liver injury are rare. We present a 56-year-old woman who developed atorvastatin-induced grade III acute liver injury with concurrent rhabdomyolysis that worsened after rechallenging, which highlighted the need for pharmacovigilance with statins. The Roussel Uclaf Causality Assessment Method and Revised Electronic Causality Assessment Method both showed that atorvastatin was highly probable in causing hepatotoxicity. To our knowledge, this is the first reported case of concurrent drug-induced liver injury and rhabdomyolysis after a positive rechallenge with atorvastatin.

Indexed as

atorvastatin-induced liver injuryDILIdrug-induced liver injurypositive rechallengerhabdomyolysis

Identifiers

PMID39742213
PMCPMC11688008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.