ArticleCureus2024
Incidence, Clinicopathological Features, and Outcomes of Signet Ring Colorectal Carcinoma: A Retrospective Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Development and validation of machine learning models for predicting cancer-specific survival in colorectal signet ring cell carcinoma.BMC gastroenterology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer with significant variations in clinical characteristics and poor prognosis. However, there is limited data available in Pakistan. Therefore, we analyzed to examine the incidence, clinicopathological features, treatments, and outcomes of SRCC in colorectal cancer cases in Pakistan. Methods This study includes 214 primary signet ring cell carcinoma cases in the colon and rectum. All relevant clinical information extracts on demographic details, laboratory results, radiological findings, endoscopy, pathologic diagnoses, surgical interventions, neoadjuvant and adjuvant therapies, and their corresponding outcomes were undertaken from the same online database of hospital and analyzed using SPSS (SPSS Inc., Chicago, IL, USA), Chi-square test, and independent sample Kruskal-Wallis H test. Results The prevalence of SRCC was higher in younger patients (<50 years), 184 (86%). SRCC was more common in advanced stages T3 and T4, with 210 (98%) cases and 106 cases (49.5%) belonging to stage N2. In 27 cases (12.6%), there was already distant metastasis. The most common site of recurrent disease in SRCC patients was the peritoneum in about 50 (51.5%) patients, followed by multi-site metastases involving the lung, liver, bones, and lymph nodes. Conclusion Signet ring cell colorectal cancer (SRCC) manifests in Pakistan at a younger age and is diagnosed at a more advanced stage, often accompanied by peritoneal metastasis with elevated levels of recurrence due to relatively low rates of screening and the absence of national cancer data and guidelines. It is imperative that these issues should be addressed in order to alleviate the burden of this disease in our population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.