Evidence map›Paper›PMID 39742107›Full record

ReviewContact (Thousand Oaks (Ventura County, Calif.))

Channels, Transporters, and Receptors at Membrane Contact Sites.

Maria Casas, Eamonn James Dickson

Abstract readReview
In one paragraph

Review in Contact (Thousand Oaks (Ventura County, Calif.)). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maria CasasDepartment of Physiology and Membrane Biology, University of California, Davis, CA, USA.
Eamonn James DicksonDepartment of Physiology and Membrane Biology, University of California, Davis, CA, USA.ORCID https://orcid.org/0000-0001-8619-7630

Funding

Alpha-Synuclein aberrantly modifies the nanoscale distribution and function of ion channels to promote neuronal cytotoxicityRF1NS131379 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES · 2023 to 2023
$1.7M
Lysosomal control of plasma membrane -endoplasmic reticulum membrane contacts regulates neuronal excitabilityR35GM149211 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eamonn James Dickson · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM149211NINDS NIH HHS RF1 NS131379
6 · The paper itself

Abstract

Membrane contact sites (MCSs) are specialized regions where two or more organelle membranes come into close apposition, typically separated by only 10-30 nm, while remaining distinct and unfused. These sites play crucial roles in cellular homeostasis, signaling, and metabolism. This review focuses on ion channels, transporters, and receptors localized to MCSs, with particular emphasis on those associated with the plasma membrane and endoplasmic reticulum (ER). We discuss the molecular composition and functional significance of these proteins in shaping both organelle and cellular functions, highlighting their importance in excitable cells and their influence on intracellular calcium signaling. Key MCSs examined include ER-plasma membrane, ER-mitochondria, and ER-lysosome contacts. This review addresses our current knowledge of the ion channels found within these contacts, the dynamic regulation of MCSs, their importance in various physiological processes, and their potential implications in pathological conditions.

Indexed as

calcium (Ca2+)calcium-induced calcium release (CICR)endoplasmic reticulum (ER)ion channelsIP3 receptorjunctophilin (JPH)large conductance Ca2+-activated K+ channel (BKCa)membrane contact sites (MCS)neurodegenerationniemann-Pick type C1 (NPC1)orairyanodine receptors (RyR)stromal interaction molecule (Stim)transient receptor potential cation channel subfamily M member 4 (TRPM4)voltage-gated calcium channel (CaV)voltage-gated potassium channel (KV)

Identifiers

PMID39742107
PMCPMC11686659

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.