Evidence map›Paper›PMID 39742002›Full record

ArticleCardiovascular therapeutics2024

Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans.

Liang Hong, Hong Yue, Dunpeng Cai, Autumn DeHart, Gretel Toloza-Alvarez, Lili Du, Xianwu Zhou, Xiaoping Fan, Huanlei Huang, Shiyou Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Liang HongDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Hong YueDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
Dunpeng CaiDepartment of Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA.
Autumn DeHartDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
Gretel Toloza-AlvarezDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
Lili DuDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
Xianwu ZhouDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Xiaoping FanDepartment of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-7067-7450
Huanlei HuangDepartment of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Shiyou ChenDepartment of Surgery, University of Missouri School of Medicine, Columbia, Missouri, USA.
Shaik O RahamanDepartment of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA.
Jian ZhuangDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.ORCID https://orcid.org/0009-0005-2479-2270
Wei LiDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.ORCID https://orcid.org/0000-0002-7973-6242

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Reagan Curtis · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Novel mechanism of smooth muscle phenotypic modulation and vascular remodelingR01HL119053 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHEN, SHIYOU · 2014 to 2023
$3.8M
Thymidine Phosphorylase: a Novel Target of Antiplatelet TherapyR15HL145573 · NHLBI · MARSHALL UNIVERSITY · PI LI, WEI · 2019 to 2022
$878k
BLRD VA I01 BX006161NHLBI NIH HHS R01 HL119053NHLBI NIH HHS R15 HL145573NIGMS NIH HHS P20 GM103434NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin IIAorta, AbdominalAortic Aneurysm, AbdominalDisease Models, AnimalMatrix Metalloproteinase 2Mice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleSignal TransductionThymidine PhosphorylaseVascular RemodelingAnimalsCell LineCells, CulturedDisease ProgressionAngiotensin IIInflammation MediatorsMatrix Metalloproteinase 2MMP2 protein, humanMmp2 protein, mouseProto-Oncogene Proteins c-aktThymidine PhosphorylaseTransforming Growth Factor beta1TYMP protein, humanabdominal aortic aneurysminflammationmatrix metalloproteinasethymidine phosphorylasevascular smooth muscle cells

Identifiers

PMID39742002
PMCPMC11669429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.