ArticleFrontiers in epidemiology2024
Approximation of the infection-age-structured SIR model by the conventional SIR model of infectious disease epidemiology.
Article in Frontiers in epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
During the SARS-CoV-2 pandemic, the effective reproduction number (R-eff) has frequently been used to describe the course of the pandemic. Analytical properties of R-eff are rarely studied. We analytically examine how and under which conditions the conventional susceptible-infected-removed (SIR) model (without infection age) serves as an approximation to the infection-age-structured SIR model. Special emphasis is given to the role of R-eff, which is an implicit parameter in the infection-age-structured SIR model and an explicit parameter in the approximation. The analytical findings are illustrated by a simulation study about an hypothetical intervention during a SARS-CoV-2 outbreak and by historical data from an influenza outbreak in Prussian army camps in the region of Arnsberg (Germany), 1918-1919.
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