Evidence map›Paper›PMID 39741841›Full record

ArticleACS omega2024

Targeting Protein Disorder for the Remediation of Antimicrobial Resistance.

Jack O' Callaghan, Michael P Ryan, Sarah Hudson, Damien Thompson

Abstract read
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jack O' CallaghanDepartment of Physics, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0002-0687-8450
Michael P RyanDepartment of Applied Sciences, TUS Midwest, Limerick V94 EC5T, Ireland.
Sarah HudsonBernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0002-6718-2190
Damien ThompsonDepartment of Physics, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.ORCID https://orcid.org/0000-0003-2340-5441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The remediation of antimicrobial resistance (AMR) is a fundamental challenge for global healthcare. Intrinsically disordered proteins (IDPs) are recognized drug targets for neurodegeneration and cancer but have not been considered to date for AMR. Here, a novel link between structural disorder and AMR is identified by mapping predicted disorder profiles onto existing transcriptomic data for resistant and susceptible

Identifiers

PMID39741841
PMCPMC11683595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.