ArticleACS omega2024
Curcumin Encapsulation in Aluminum Fumarate Metal-Organic Frameworks for Enhanced Stability and Antioxidant Activity.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Article
- Development of a 3D collagen type I hydrogel scaffold for modeling hyperglycemia-induced spinal neuronal damage and therapeutic evaluation.Histochemistry and cell biology · 2026Article
- Curcumin-Loaded Nanoscale Metal-Organic Frameworks for Therapeutic Applications in Cancer.Nanomaterials (Basel, Switzerland) · 2025Review
- Green synthesis and characterization of Curcumin functionalized MIL-88 A metal organic framework for reactive blue dye removal optimized by response surface methodology.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin (Cur) is a great candidate for antioxidant applications; however, due to its low solubility and poor bioavailability, it remains only hardly employed as a therapeutic agent. Moreover, curcumin is very unstable and tends to degrade quickly. Metal-organic frameworks (MOFs) have gained great attention in the field of drug loading due to their diversity and tunability, so they are seen as great candidates for hosting curcumin. Aluminum fumarate MOF (AlMOF) was able to hold curcumin successfully by the wet impregnation technique. The resulting system significantly increased the stability of curcumin, so it went from degrading to 58.9% after 3 days to degrading to 16% after 10 days when entrapped in AlMOF. In addition, the antioxidant activity of curcumin was also greatly boosted in the MOF-Cur system compared to curcumin in its free state. These results open the door to an in-depth study of MOF-Cur systems as great therapeutic agents due to the enhancement of the therapeutic properties of curcumin, all while protecting it, favoring its solubility, and maintaining its stability.
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Registered trials
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