Evidence map›Paper›PMID 39741661›Full record

ArticleFrontiers in cardiovascular medicine2024

Comparison of Del Nido and histidine-tryptophan-ketoglutarate cardioplegia solutions: an animal study with prolonged ischaemia.

Alexandro Hoyer, Maja-Theresa Dieterlen, Jagdip Kang, Hanna Oetzel, Karoline Wiesner, Kristin Klaeske, Philipp Kiefer, Susann Oßmann, André Ginther, Martin Kostelka and 2 more

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In one paragraph

Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandro Hoyer *Heart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Maja-Theresa Dieterlen *Heart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Jagdip KangHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Hanna OetzelHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Karoline WiesnerHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Kristin KlaeskeHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Philipp KieferHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Susann OßmannHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
André GintherHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Martin KostelkaHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Suzanne de WahaHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.
Michael A BorgerHeart Centre Leipzig, University Clinic of Cardiac Surgery, HELIOS Clinic, University Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Myocardial protection is important for a successful procedure cardiac surgery, and the key element of myocardial protection is cardioplegia. We compared Del Nido cardioplegia (DN) and Bretschneider histidine-tryptophan-ketoglutarate cardioplegia (HTK) regarding cardioprotective effects in a porcine model of prolonged ischaemia. Methods: Landrace pigs weighing 50-60 kg were randomized to receive either DN ( Results: Pressure-volume measurements revealed better systolic and diastolic left ventricular performance in DN as compared to HTK (both Conclusions: In this porcine model with prolonged ischaemia, DN was superior to HTK in terms of haemoglobin levels, blood electrolytes, spontaneous return of sinus rhythm, left ventricular function, and endothelial injury. Histomorphological parameters indicative of ischaemia/reperfusion injury, oxidative stress and mitochondrial function as well as apoptosis-inducing factors did not differ.

Indexed as

animal modelBretschneider solutioncustodiolDel Nido solutionhistidine-tryptophan-ketoglutarate solutionischaemiasingle-shot cardioplegia

Identifiers

PMID39741661
PMCPMC11686485

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.