ArticleJACC. Advances2024
Antibodies Against Phosphorylcholine in Prediction of Cardiovascular Disease Among Women: A Population-Based Prospective Cohort Study.
Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Estrogen deprivation induces hepatic inflammation, Indoleamine-2,3-dioxygenase 1, tryptophan catabolism, and plasma cholesterol.Scientific reports · 2026Article
- Do human B-1 lymphocytes truly exist?Frontiers in immunology · 2026Review
- Targeting the Th17/Treg axis: from immunological insights to therapeutic avenues in atherosclerosis.Frontiers in immunology · 2026Review
- Atherosclerosis features in rheumatic diseases - focus on peripheral artery disease.Frontiers in immunology · 2026Review
- Current Prognostic Biomarkers for Peripheral Arterial Disease: A Comprehensive Systematic Review of the Literature.Metabolites · 2025Review
- Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?Biomolecules · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antibodies against phosphorylcholine (anti-PC) have been reported as associated with protection against atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory diseases. Underlying potential mechanisms have been demonstrated and include anti-inflammatory, clearance of dead cells, and inhibition of oxidized low-density lipoprotein effects. Objectives: This study examined the role of IgM anti-PC and incident CVD among women, where less is known than among men in the general population. Methods: In a total of 932 women, age 66 ± 6 years at baseline, from the population-based Swedish Mammography Cohort, IgM anti-PC levels of sera were measured using Enzyme Linked Immunosorbent assay. Prospective associations with any first CVD, ischemic heart disease (IHD), myocardial infarction (MI), and ischemic stroke were assessed using Cox proportional hazard regression, generating HRs and 95% CIs. The model was adjusted for potential confounding factors. Results: Over the course of 16 years (13,033 person-years), we identified 113 cases of composite CVD, 69 cases of IHD, 44 cases of MI, and 50 cases of ischemic stroke. IgM anti-PC was statistically significantly inversely associated with risk of CVD, IHD, and MI, but not with ischemic stroke. Comparing the highest tertile with lowest, we observed multivariable-adjusted HR of 0.27 (95% CI: 0.11-0.68; Conclusions: IgM anti-PC may play an active role in inhibition of CVD development in women, especially MI. Furthermore, IgM anti-PC levels may play a role in identifying those at risk.
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