Evidence map›Paper›PMID 39741560›Full record

ReviewNeuroImmune pharmacology and therapeutics2024

Cannabis use, oral dysbiosis, and neurological disorders.

Amber A Hazzard, Marice McCrorey, Tabinda Salman, Douglas E Johnson, Zhenwu Luo, Xiaoyu Fu, Andrew P Keegan, Andreana Benitez, Sylvia Fitting, Wei Jiang

Abstract readReview
In one paragraph

Review in NeuroImmune pharmacology and therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amber A HazzardDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Marice McCroreyDepartment of Molecular and Cellular Biology and Pathobiology, Medical University of South Carolina, Charleston, SC, USA.
Tabinda SalmanDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Douglas E JohnsonDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Zhenwu LuoDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Xiaoyu FuDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Andrew P KeeganDivision of Multiple Sclerosis and Neuroimmunology, Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Andreana BenitezDepartment of Neurology, Medical University of South Carolina, Charleston, SC, USA.
Sylvia FittingDepartment of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.

Funding

MUSC Minority Student Development ProgramR25GM072643 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE, RINKER, JENNIFER ANNE · 2005 to 2023
$5.8M
Investigating the effect of oral microbiome on cognition in HIV-infected chronic cannabis usersR01DA055523 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Sylvia Fitting, Wei Jiang · 2022 to 2026
$3.5M
Endocannabinoid-mediated neuroprotection in models of neuroAIDS in vivoR01DA045596 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FITTING, SYLVIA · 2018 to 2022
$1.9M
MUSC IMSDT32GM152386 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ERGUL, ADVIYE, RINKER, JENNIFER ANNE · 2024 to 2024
$460k
Investigate B cell perturbations and immune reconstitution failure in response to antiretroviral therapy in HIV-infected cocaine usersR03DA057164 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2022 to 2023
$302k
CSRD VA I01 CX002422NIDA NIH HHS R01 DA045596NIDA NIH HHS R01 DA055523NIDA NIH HHS R03 DA057164NIGMS NIH HHS R25 GM072643NIGMS NIH HHS T32 GM152386
6 · The paper itself

Abstract

Cannabis (marijuana) is a leafy plant that has medical, recreational, and other uses. Cannabis is socially accepted and widely used throughout the United States. Though cannabis use is increasingly gaining popularity, studies detail the deleterious effects of chronic cannabis smoking on mental health, as well as the immunosuppressive properties of cannabinoids. Additionally, oral dysbiosis induced by cannabis smoking serves as a novel catalyst for neurological abnormalities, potentially possible through microbial translocation via the oral-brain axis. This review summarizes the effects and link of smoking cannabis on neurological abnormalities, immunity, and oral microbiome.

Indexed as

cannabiscentral nervous systemdysbiosismental healthmicrobiome

Identifiers

PMID39741560
PMCPMC11683879

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.