Evidence map›Paper›PMID 39741495›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2024

Evaluation of a Decentralized Donor-Derived Cell-Free DNA Assay for Kidney Allograft Rejection Monitoring.

Alexandre Loupy, Anaïs Certain, Narin S Tangprasertchai, Maud Racapé, Cindy Ursule-Dufait, Kawthar Benbadi, Marc Raynaud, Evgeniya Vaskova, Corina Marchis, Sílvia Casas and 6 more

Abstract readEvaluation Study
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Diagnostic Potential of Urine CXCL10 and Donor-Derived cfDNA in Kidney Transplant Rejection.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  4. Article
  5. Review
  6. Longitudinal Monitoring of Donor-Derived Cell-Free DNA Supports Risk Stratification in Kidney Transplant Recipients With Allograft Dysfunction.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  7. Review
  8. Noninvasive Diagnosis of Kidney Allograft Rejection.Journal of the American Society of Nephrology : JASN · 2025
    Review
  9. Review
  10. %dd-cfDNA: The New Frontier for Heart/Lung Transplant Surveillance?Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
  11. Review
  12. Immune Landscape in Kidney Transplantation.Journal of inflammation research · 2025
    Review
  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexandre LoupyUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Anaïs CertainUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Narin S TangprasertchaiCareDx, Brisbane, CA, United States.
Maud RacapéUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Cindy Ursule-DufaitUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Kawthar BenbadiUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Marc RaynaudUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Evgeniya VaskovaCareDx, Brisbane, CA, United States.
Corina MarchisCareDx, Brisbane, CA, United States.
Sílvia CasasCareDx, Brisbane, CA, United States.
Tim HagueCareDx, Brisbane, CA, United States.
Oriol BestardDepartment of Nephrology and Kidney Transplantation, Vall d'Hebron University Hospital, Vall d' Hebrón Research Institute, Vall d' Hebrón Barcelona Campus Hospital, Barcelona Autonomous University, Barcelona, Spain.
Delphine KervellaDepartment of Nephrology and Kidney Transplantation, Vall d'Hebron University Hospital, Vall d' Hebrón Research Institute, Vall d' Hebrón Barcelona Campus Hospital, Barcelona Autonomous University, Barcelona, Spain.
Carmen LefaucheurUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.
Thierry ViardCareDx, Brisbane, CA, United States.
Olivier AubertUniversité Paris Cité, Institut national de la santé et de la recherche médicale (INSERM) U970, Paris Institute for Transplantation and Organ Regeneration PITOR, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Donor-derived cell-free DNA (dd-cfDNA) is an emerging non-invasive biomarker for allograft injury detection. This study aimed to evaluate a new, decentralized dd-cfDNA testing kit against a centralized dd-cfDNA testing service broadly utilized in the United States. Kidney transplant recipients with decentralized and centralized dd-cfDNA measurements and concomitant kidney allograft biopsies were included in the study. 580 kidney allograft recipients from 3 referral centers were included for 603 total evaluations. Correlation between assays was evaluated using r-squared (

Indexed as

Cell-Free Nucleic AcidsGraft RejectionKidney TransplantationTissue DonorsAdultAgedAllograftsBiomarkersBiopsyFemaleHumansMaleMiddle AgedBiomarkersCell-Free Nucleic Acidsallograft rejectionAlloSeqdd-cfDNAliquid biopsynon-invasive diagnosis

Identifiers

PMID39741495
PMCPMC11685011

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.