Evidence map›Paper›PMID 39741419›Full record

ArticleAging cell2025

P2Y

Amit Chougule, Chunbin Zhang, Jordan Denbow, Nickolas Vinokurov, Devin Mendez, Elizabeth Vojtisek, Joseph Gardinier

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amit ChouguleBone and Joint Center, Henry Ford Health System, Detroit, Michigan, USA.
Chunbin ZhangBone and Joint Center, Henry Ford Health System, Detroit, Michigan, USA.
Jordan DenbowBone and Joint Center, Henry Ford Health System, Detroit, Michigan, USA.
Nickolas VinokurovSchool of Medicine, Wayne State University, Detroit, Michigan, USA.
Devin MendezSchool of Medicine, Wayne State University, Detroit, Michigan, USA.
Elizabeth VojtisekBone and Joint Center, Henry Ford Health System, Detroit, Michigan, USA.
Joseph GardinierBone and Joint Center, Henry Ford Health System, Detroit, Michigan, USA.ORCID 0000-0002-8651-8913

Funding

Modifying the mechanotransduction of bone by targeting purinergic receptorsR01AR076378 · NIAMS · HENRY FORD HEALTH SYSTEM · PI GARDINIER, JOSEPH DANIEL · 2020 to 2024
$1.6M
Chiesi Farmaceutici R01AR076378NIAMS NIH HHS R01 AR076378
6 · The paper itself

Abstract

As the aging population continues to grow, the incidence of osteoporotic fractures increases and is compounded by our lack of therapeutic strategies that increase bone formation. Although exercise and physical activity play a key role in maintaining bone mass throughout our lives, the loads and exertion required to elicit an anabolic response becomes exceedingly difficult to achieve with age. Based on previous work, the P2Y

Indexed as

OsteogenesisPhysical Conditioning, AnimalPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y2AnimalsMaleMiceMice, Inbred C57BLOsteoclastsOsteocytesPurinergic P2Y Receptor AntagonistsReceptors, Purinergic P2Y2mechanobiologyosteoporosispurinergic signaling

Identifiers

PMID39741419
PMCPMC12074023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.