Evidence map›Paper›PMID 39741342›Full record

SynthesisJournal of orthopaedic surgery and research2024

The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis.

Qixin Ding, Xu Wang, Yurong Liu, Yuefang Li, Di Zhang, Heling Wang, Shenhong Ma, Qiaohua Han, Weisheng Zhuang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Influence of endplate degeneration on fusion process in lateral lumbar interbody fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Special screw corridors and imaging in pelvic ring trauma.Archives of orthopaedic and trauma surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qixin DingSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Xu WangSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Yurong LiuHunan Normal University, Changshao, China.
Yuefang LiSchool of Clinical Medicine, Henan University, Zhengzhou, China.
Di ZhangSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Heling WangSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Shenhong MaSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China.
Qiaohua HanSchool of Clinical Medicine, Henan University, Zhengzhou, China.
Weisheng ZhuangSchool of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou, China. zhuang20062634@163.com.

Funding

Henan Provincial Science and Technology Research Project 232102310266
6 · The paper itself

Abstract

objectiveAnkle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment.

methodsA comprehensive and systematic search of PubMed, the Cochrane Library, Embase and web of science databases was performed, and studies that met the requirements according to the inclusion criteria were analyzed using Review Manager and STATA version 14.0. Quality assessment was performed using the Cochrane Collaboration Risk of Bias 2.0 tool. The outcome indicators were the American Orthopaedic Foot and Ankle Society Rating Scale (AOFAS) and Visual Analog Scale (VAS) scores used to evaluate the efficacy of platelet-rich plasma.

resultsA total of 10 studies met the inclusion criteria. Regarding the AOFAS score, a meta-analysis that included five randomized controlled trials (each study extracted the score results at the last follow-up time) showed no statistically significant differences between the platelet-rich plasma intervention group and the control group, and there was a great deal of heterogeneity in the results, with subgroup analyses based on disease type. (Mean Difference = 4.14, 95% CI=-0.60-8.87, p = 0.09, I

conclusionMore clinical studies are needed to further confirm the efficacy of platelet-rich plasma in ankle disorders, and the current study only suggests that platelet-rich plasma may be more effective in talus cartilage injuries than in other types of ankle disorders.

Indexed as

Ankle JointOsteoarthritisPlatelet-Rich PlasmaHumansRandomized Controlled Trials as TopicTreatment OutcomeAnkle diseasesAnkle jointFunctional restorationMeta-analysisPlatelet-rich plasma

Identifiers

PMID39741342
PMCPMC11689593

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.