Evidence map›Paper›PMID 39741290›Full record

ArticleJournal of translational medicine2024

Epilepsy and brain health: a large prospective cohort study.

Dan-Dan Zhang, Zi-Yi Wang, Ya-Ru Zhang, Pei-Yang Gao, Wei Zhang, Yan Fu, Hao-Chen Chi, Li-Yun Ma, Yi-Jun Ge, Xiao-Yu He and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Correlation Between Liver Function and Risk of Post-Stroke Epilepsy.Journal of multidisciplinary healthcare · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dan-Dan Zhang *Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Zi-Yi Wang *Department of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
Ya-Ru Zhang *Department of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
Pei-Yang GaoDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Wei ZhangInstitute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.
Yan FuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Hao-Chen ChiDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Li-Yun MaDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China.
Yi-Jun GeDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
Xiao-Yu HeDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
Jia YouInstitute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.
Wei ChengDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China.
Jian-Feng FengInstitute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China. dr.tanlan@163.com.
Jin-Tai YuDepartment of Neurology and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn.ORCID 0000-0002-2532-383X

Funding

111 Project B18015Excellence 2025 Talent Cultivation Program at Fudan University 3030277001National Natural Science Foundation of China 82071201, 82071997Research Start-up Fund of Huashan Hospital 2022QD002Shanghai Municipal Science and Technology Major Project 2018SHZDZX01Shanghai Rising-Star Program 21QA1408700Shanghai Talent Development Funding for The Project 2019074the Science and Technology Innovation 2030 Major Projects 2022ZD0211600ZHANGJIANG LAB, Tianqiao and Chrissy Chen Institute, the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Shanghai Center for Brain Science and Brain-Inspired Technology, Fudan University ZHANGJIANG LAB, Tianqiao and Chrissy Chen Institute, the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Shanghai Center for Brain Science and Brain-Inspired Technology, Fudan University
6 · The paper itself

Abstract

backgroundEpilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms.

methodsThe study was based on clinical diagnostic and test data from 426,527 participants in the UK Biobank, of whom 3,251 were diagnosed with epilepsy at baseline. Multiple linear and Cox regression models were used to explore the association between epilepsy, brain function, and other brain disorders.

resultsThis study demonstrated consistent deleterious effects of epilepsy on cognitive and motor function and mental health. The risk of neurological diseases and psychiatric disorders was significantly elevated in the epilepsy population during the 17-year follow-up period, according to the longitudinal analysis. We also identified several brain regions associated with epilepsy, including the pallidum, hippocampus, and precentral regions. Mediation analyses revealed mediating effects of peripheral markers and proteins (e.g., GGT, HDL, ACE2, and GDF15), suggesting that liver function and lipid metabolism may be involved in the development of other brain disorders in individuals with epilepsy.

conclusionsOur study provides robust evidence of the association between epilepsy and poor brain health, underscoring the importance of early intervention for epilepsy.

Indexed as

BrainEpilepsyAdultAgedBiomarkersCognitionFemaleHumansMaleMiddle AgedProspective StudiesBiomarkersCognitiveDementiaDepressionEpilepsyMechanismMental health

Identifiers

PMID39741290
PMCPMC11687061

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.