Evidence map›Paper›PMID 39741147›Full record

ArticleNPJ systems biology and applications2024

Open problems in synthetic multicellularity.

Ricard Solé, Núria Conde-Pueyo, Jordi Pla-Mauri, Jordi Garcia-Ojalvo, Nuria Montserrat, Michael Levin

Abstract read
In one paragraph

Article in NPJ systems biology and applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ricard SoléICREA-Complex Systems Lab, Universitat Pompeu Fabra, Dr Aiguader 88, 08003, Barcelona, Spain. ricard.sole@upf.edu.ORCID 0000-0001-6974-1008
Núria Conde-PueyoICREA-Complex Systems Lab, Universitat Pompeu Fabra, Dr Aiguader 88, 08003, Barcelona, Spain.
Jordi Pla-MauriICREA-Complex Systems Lab, Universitat Pompeu Fabra, Dr Aiguader 88, 08003, Barcelona, Spain.ORCID 0000-0003-2388-9407
Jordi Garcia-OjalvoUniversitat Pompeu Fabra, Medicine and Life Sciences Department (MELIS), Barcelona, Spain.ORCID 0000-0002-3716-7520
Nuria MontserratPluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Carrer de Baldiri i Reixac, 15-21, Barcelona, 08028, Spain.
Michael LevinAllen Discovery Center, Tufts University, Medford, MA, USA.

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERCCoG-2020 101002478 ENGINORGJohn Templeton Foundation (JTF) Grant 62212
6 · The paper itself

Abstract

Multicellularity is one of the major evolutionary transitions, and its rise provided the ingredients for the emergence of a biosphere inhabited by complex organisms. Over the last decades, the potential for bioengineering multicellular systems has been instrumental in interrogating nature and exploring novel paths to regeneration, disease, cognition, and behaviour. Here, we provide a list of open problems that encapsulate many of the ongoing and future challenges in the field and suggest conceptual approaches that may facilitate progress.

Indexed as

Synthetic BiologyAnimalsBioengineeringBiological EvolutionHumansModels, BiologicalSystems Biology

Identifiers

PMID39741147
PMCPMC11688451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.