Evidence map›Paper›PMID 39741007›Full record

ArticleLife science alliance2025

Genetic modulation of RNA splicing rescues BRCA2 function in mutant cells.

Beatriz Anjo Lima, Ana Carolina Pais, Juliette Dupont, Patrícia Dias, Noélia Custódio, Ana Berta Sousa, Maria Carmo-Fonseca, Célia Carvalho

Abstract read
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Beatriz Anjo LimaFaculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Ana Carolina PaisFaculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Juliette DupontServiço de Genética, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.ORCID 0000-0001-8257-5067
Patrícia DiasServiço de Genética, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.
Noélia CustódioFaculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.ORCID 0000-0001-9230-9870
Ana Berta SousaServiço de Genética, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.ORCID 0000-0001-5889-2492
Maria Carmo-FonsecaFaculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal carmo.fonseca@medicina.ulisboa.pt.ORCID 0000-0002-3402-7143
Célia CarvalhoFaculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal celiacarv@edu.ulisboa.pt.ORCID 0000-0002-5980-595X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variants in the hereditary cancer-associated

Indexed as

BRCA2 ProteinCRISPR-Cas SystemsMutationRNA SplicingBRCA1 ProteinBreast NeoplasmsCell Line, TumorDNA RepairFemaleGene EditingHumansNonsense Mediated mRNA DecayRad51 RecombinaseRNA, MessengerBRCA1 ProteinBRCA2 ProteinBRCA2 protein, humanRad51 RecombinaseRNA, Messenger

Identifiers

PMID39741007
PMCPMC11707380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.