Evidence map›Paper›PMID 39740788›Full record

ArticleBrain and behavior2025

Association Between Depressive Symptoms and Comorbidities Among Elderly Diabetic Individuals in China.

Luyao Qiao, Xin Pan, Tianpei Li, Shouqin Yi, Zhenyu Tang

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Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Luyao QiaoDepartment of Neurology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID https://orcid.org/0000-0001-9463-5848
Xin PanThe Second Department of Neurology, Jiangxi Provincial People's Hospital, Clinical College of Nanchang Medical College, First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Tianpei LiDepartment of Neurology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Shouqin YiDepartment of Neurology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhenyu TangDepartment of Neurology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

Funding

National Natural Science Foundation of China 82060214Natural Science Foundation of Jiangxi Province 20212BAB206047Science and Technology Innovation 2030 - Major Project 2021ZD0201805
6 · The paper itself

Abstract

backgroundDiabetic individuals are at an increased risk of mental illness and comorbidities. However, the precise association between depressive symptoms and comorbidity remains uncertain. Our study aimed to investigate this relationship among elderly Chinese diabetic patients.

methodsData from the China Health and Retirement Longitudinal Study (CHARLS) in 2020 were utilized for the cross-sectional analysis. Depressive status was defined as the dependent variable, while the presence, number, and type of comorbidities served as independent variables. Logistic regression analyses were performed, adjusting for potential demographic factors, and health status and functioning factors.

resultsOur findings indicate that diabetic patients with complications are more likely to experience depression. With the exception for dyslipidemia (OR = 1.195, 95% CI: 0.969, 1.475), individuals with hypertension, heart disease, stroke, kidney disease, memory-related disease, or arthritis/rheumatism were prone to develop depressive status in the fully adjusted model. After adjusting for covariates, diabetic patients with memory-related diseases exhibited the most pronounced association with depressive symptoms (OR = 2.673, 95% CI: 1.882, 3.797). Furthermore, an increasing number of depression-related comorbidities strengthened the association (p < 0.05). Sensitivity analysis revealed that there were no significant differences stratified by gender or marital status (p < 0.05).

conclusionsIn the elderly diabetic population in China, the presence, number, and type of comorbidities were independently associated with depressive symptoms. Diabetic patients with memory-related diseases displayed the highest likelihood of experiencing depressive status. These findings underscore the importance of implementing effective strategies for multimorbidity management in diabetic patients.

Indexed as

ComorbidityDepressionAgedAged, 80 and overChinaCross-Sectional StudiesDiabetes ComplicationsDiabetes MellitusFemaleHumansLongitudinal StudiesMaleMiddle AgedCHARLScomorbiditydepressive symptomsdiabetes mellitus

Identifiers

PMID39740788
PMCPMC11688112

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