ReviewBrain and behavior2025
The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post-Traumatic Stress Disorder.
Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nucleus accumbens GLP-1 signaling and its role in reward and metabolic regulation: a systematic review.Frontiers in neuroanatomy · 2026Pooled it
- Brief transdiagnostic cognitive behavioral therapy and expressive writing for hazardous drinking and posttraumatic stress symptoms among sexual and gender minority adults: Pilot trial protocol.Contemporary clinical trials communications · 2026Article
- The gut microbiota-immune-brain axis in post-traumatic stress disorder: mechanistic integration and translational prospects.Frontiers in immunology · 2026Review
- Behavior-psychological linkages: how health literacy enhances life satisfaction in Chinese university students through the mediation of persistent exercise and emotional management ability.Frontiers in psychology · 2026Article
- Independent Contributions of Social Functioning Deficits and Internalized Stigma to Quality of Life in Clinically Stable Patients with Schizophrenia: A Hierarchical Regression Analysis.Psychology research and behavior management · 2026Article
- Research Progress on the Pathogenesis of Post-Stroke Depression.ACS omega · 2025Review
- Understanding Cancer Screening Behavior in South Korea: A Biopsychosocial Approach to Regional Differences.Healthcare (Basel, Switzerland) · 2025Article
- Posttraumatic stress disorder neurophysiology and clinical correlates in pediatric critical care: conceptualizing a PICU-PTSD framework.Frontiers in pediatrics · 2025Review
- Cancer as trauma: multidimensional determinants of PTSD across the disease course. A narrative integrative review.Frontiers in psychology · 2025Review
- The impact of smartphone addiction on creativity among college students: a moderated mediation model of negative emotion and perceived social support.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis extensive literature review investigates the relationship between post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD), focusing on the neurobiological changes associated with their co-occurrence. Given that these disorders frequently coexist, we analyze mechanisms through which alcohol serves as a coping strategy for PTSD symptoms, particularly highlighting the drinking-to-cope self-medication model, which suggests that alcohol use exacerbates PTSD symptoms and complicates recovery.
methodsA systematic literature search was conducted across multiple databases, including PubMed and Google Scholar, to identify studies examining the intersection of the biopsychosocial model with PTSD, AUD, and associated neural alterations.
resultsFindings demonstrate that chronic PTSD is associated with progressive dysfunction in the amygdala, hippocampus, prefrontal cortex, hypothalamic-pituitary-adrenal axis, and white matter pathways. Also, our findings underscore alterations within the reward system, prefrontal cortex, hippocampus, amygdala, basal ganglia, and hypothalamic-pituitary-adrenal axis that contribute to the pathophysiology of AUD. Our results support the notion that a biopsychosocial framework is essential for contemporary addiction treatment, particularly in the context of alcohol addiction and PTSD.
conclusionPTSD frequently leads individuals to use alcohol as a maladaptive coping strategy, ultimately resulting in neuroadaptive alterations across critical brain regions. These neurobiological changes contribute to the development and maintenance of AUD. The findings reiterate the necessity of employing a biopsychosocial model in treating individuals grappling with both PTSD and AUD. This model allows for a comprehensive understanding of the unique challenges faced by this population, integrating biological, psychological, and social factors that influence recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.