Evidence map›Paper›PMID 39740351›Full record

ArticleJournal of neurophysiology2025

Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex.

Guillermo Gonzalez-Burgos, Takeaki Miyamae, Yosuke Nishihata, Olga L Krimer, Kirsten Wade, Kenneth N Fish, Dominique Arion, Zhao-Lin Cai, Mingshan Xue, William R Stauffer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Guillermo Gonzalez-BurgosDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-1650-8111
Takeaki MiyamaeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0001-8917-9542
Yosuke NishihataDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Olga L KrimerDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Kirsten WadeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Kenneth N FishDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-1774-3815
Dominique ArionDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Zhao-Lin CaiDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, United States.
Mingshan XueDepartment of Neuroscience, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0003-1463-8884
William R StaufferDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
David A LewisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-3225-6778

Funding

SCHIZOPHRENIA AND CORTICAL DOPAMINE/GABA INTERACTIONSR01MH043784 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEWIS, DAVID A · 1988 to 2023
$7.2M
GABA Neurons and Cortical Circuitry in SchizophreniaR37MH043784 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEWIS, DAVID A · 2001 to 2010
$6.8M
Deciphering the GABA neuron alterations in schizophreniaR01MH119701 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N · 2019 to 2023
$2.2M
Activity-Dependent Mechanisms Regulating Synaptic Excitation and Inhibition in Neural CircuitsR01MH117089 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI XUE, MINGSHAN · 2018 to 2022
$2.0M
Request for an Olympus VS200 slide scannerS10MH126905 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FISH, KENNETH N, WATKINS, SIMON C · 2021 to 2021
$370k
HHS | NIH | National Institute of Mental Health (NIMH) MH043784HHS | NIH | National Institute of Mental Health (NIMH) MH117089NIMH NIH HHS R01 MH043784NIMH NIH HHS R01 MH117089NIMH NIH HHS R01 MH119701NIMH NIH HHS R37 MH043784NIMH NIH HHS S10 MH126905NSF | Directorate for Biological Sciences (BIO) Neuronex 2015276
6 · The paper itself

Abstract

The primate dorsolateral prefrontal cortex (DLPFC) displays unique in vivo activity patterns, but how in vivo activity regulates DLPFC pyramidal neuron (PN) properties remains unclear. We assessed the effects of in vivo Kir2.1 overexpression, a genetic silencing tool, on synapses in monkey DLPFC PNs. We show for the first time that recombinant ion channel expression successfully modifies the excitability of primate cortex neurons, producing effects on synaptic properties apparently different from those in the rodent cortex.

Indexed as

Potassium Channels, Inwardly RectifyingPrefrontal CortexPyramidal CellsSynapsesAnimalsExcitatory Postsynaptic PotentialsMacaca mulattaMaleKir2.1 channelPotassium Channels, Inwardly RectifyingEPSCIPSCKir2.1 channelsnonhuman primateprefrontal cortex

Identifiers

PMID39740351
PMCPMC12208097

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.