ArticleAmerican journal of physiology. Heart and circulatory physiology2025
Endothelial cell-selective adhesion molecule deficiency exhibits increased pulmonary vascular resistance due to impaired endothelial nitric oxide signaling.
Vadym Buncha, Liwei Lang, Katie Anne Fopiano, Daria V Ilatovskaya, Gaston Kapuku, Alexander D Verin, Zsolt Bagi
Abstract read
In one paragraphArticle in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Vadym BunchaDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-8582-6957 Liwei LangDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Katie Anne FopianoDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.
Daria V IlatovskayaDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0003-4832-4170 Gaston KapukuDepartment of Medicine, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0002-0854-1413 Alexander D VerinVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0003-0627-7185 Zsolt BagiDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, United States.ORCID 0000-0001-8755-2980 Funding
Calpain/talin/MLCP axis in pulmonary endothelial barrier regulationR01HL158909 · NHLBI · AUGUSTA UNIVERSITY · PI SU, YUNCHAO, VERIN, ALEXANDER D · 2022 to 2025
$2.9MHDAC9 nuclear/cytoplasmic shuttling in pulmonary vascular endothelial barrier regulationR01HL157440 · NHLBI · AUGUSTA UNIVERSITY · PI VERIN, ALEXANDER D · 2022 to 2025
$1.5MAmerican Heart Association (AHA) 24TPA1301778American Heart Association (AHA) 917057NHLBI NIH HHS R01 HL157440NHLBI NIH HHS R01 HL158909
6 · The paper itselfAbstract
Endothelial cell-selective adhesion molecule (ESAM) is a member of tight junction molecules, highly abundant in the heart and the lung, and plays a role in regulating endothelial cell permeability. We previously reported that mice with genetic ESAM deficiency (
Indexed as
Cell Adhesion MoleculesEndothelial CellsEndothelium, VascularNitric OxideNitric Oxide Synthase Type IIIPulmonary ArteryPulmonary CirculationVascular Resistance15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsBradykininLungMaleMiceMice, Inbred C57BLMice, Knockout15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidBradykininCell Adhesion MoleculesNitric OxideNitric Oxide DonorsNitric Oxide Synthase Type IIINos3 protein, mouseVasodilator AgentsESAMnitric oxide synthasepulmonary arterypulmonary vascular resistance
Identifiers
PMID39740345
PMCPMC12269549
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