Evidence map›Paper›PMID 39740142›Full record

ArticleOral diseases2025

Effect of Oral Inflammatory Burden on Size and Stage of Oral Tongue Cancer.

Orvokki Saraneva, Jussi Furuholm, Jaana Hagström, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Välimaa, Hellevi Ruokonen

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In one paragraph

Article in Oral diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Orvokki SaranevaDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Jussi FuruholmDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Jaana HagströmDepartment of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Timo SorsaDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Ville RitaDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Taina TervahartialaDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Hannamari VälimaaDepartment of Oral and Maxillofacial Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Hellevi RuokonenDepartment of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.

Funding

Helsingin ja Uudenmaan Sairaanhoitopiiri
6 · The paper itself

Abstract

objectiveOral tongue squamous cell carcinoma is an aggressive life-threatening disease, the prognosis of which is affected by tumor stage and size. We retrospectively studied whether oral inflammatory burden and established tongue carcinoma etiological factors exert an impact on tumor size and stage. MATERIALS AND

methodsMedical records of 183 subjects diagnosed with tongue carcinoma at Helsinki University Hospital were investigated. Data on sex, smoking habits, alcohol consumption, and oral inflammatory burden were assessed by the Periodontal Burden Index, Total Dental Index, and Panorama Tomography Index. In addition, Candida hyphae in histological samples, and tumor size and stage were recorded and analyzed. History of oral potentially malignant disorders was also investigated.

resultsIncreased oral inflammatory burden, male sex, and smoking were associated significantly with larger size and advanced stage of cancer, whereas oral Candida hyphae were not associated with size of tongue carcinoma but were associated with female sex.

conclusionMale sex, oral inflammatory burden, and smoking were more common in patients with a large and advanced stage of tongue carcinoma. Thus, oral and periodontal infections and their pro-inflammatory effects may eventually promote carcinoma growth and advance the stage, especially in males.

Indexed as

Carcinoma, Squamous CellTongue NeoplasmsAdultAgedAged, 80 and overAlcohol DrinkingCandidaCandidiasis, OralFemaleHumansMaleMiddle AgedNeoplasm StagingPeriodontal IndexRetrospective StudiesSex FactorsCandidainflammatory burdenoral cancer size and stagesexsmokingsquamous cell carcinoma

Identifiers

PMID39740142
PMCPMC12319356

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.