Evidence map›Paper›PMID 39740054›Full record

ReviewJournal of medical virology2025

RNA Modifications and Their Role in Regulating KSHV Replication and Pathogenic Mechanisms.

S Schultz, K Gomard-Henshaw, M Muller

Abstract readReview
In one paragraph

Review in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S SchultzMicrobiology Department, University of Massachusetts, Amherst, Massachusetts, USA.
K Gomard-HenshawMicrobiology Department, University of Massachusetts, Amherst, Massachusetts, USA.
M MullerMicrobiology Department, University of Massachusetts, Amherst, Massachusetts, USA.ORCID 0000-0002-0056-3589

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
RNA Modifications and Turnover during Viral-induced DecayR35GM138043 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MULLER, MANDY · 2020 to 2024
$2.0M
M.M. is supported by NIH grant R35GM138043; K.G.-H. is supported by a National Research Service Award T32 GM139789 from the National Institutes of Health.NIGMS NIH HHS R35 GM138043NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

Kaposi's sarcoma-associated herpesvirus is an oncogenic gammaherpesvirus that plays a major role in several human malignancies, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The complexity of KSHV biology is reflected in the sophisticated regulation of its biphasic life cycle, consisting of a quiescent latent phase and virion-producing lytic replication. KSHV expresses coding and noncoding RNAs, including microRNAs and long noncoding RNAs, which play crucial roles in modulating viral gene expression, immune evasion, and intercellular communication. Recent studies have highlighted the importance of RNA modifications, also known as the epitranscriptome, in regulating KSHV-encoded RNAs, adding a novel layer of posttranscriptional control previously unknown. These RNA modifications, such as N

Indexed as

Gene Expression Regulation, ViralHerpesvirus 8, HumanRNA, ViralVirus ReplicationHumansMicroRNAsRNA Processing, Post-TranscriptionalSarcoma, KaposiVirus LatencyMicroRNAsRNA, ViralepitranscriptomeKaposi sarcomaKSHVnoncoding RNARNARNA modificationsviral transcripts

Identifiers

PMID39740054
PMCPMC12400198

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.