Evidence map›Paper›PMID 39740007›Full record

ArticleInternational journal of cancer2025

Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes.

Pooja Mittal, Francesca Battaglin, Yasmine Baca, Joanne Xiu, Alex Farrell, Shivani Soni, Jae Ho Lo, Lesly Torres-Gonzalez, Sandra Algaze, Priya Jayachandran and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Pooja MittalNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-2156-1419
Francesca BattaglinNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Yasmine BacaCaris Life Sciences, Phoenix, Arizona, USA.
Joanne XiuCaris Life Sciences, Phoenix, Arizona, USA.
Alex FarrellCaris Life Sciences, Phoenix, Arizona, USA.
Shivani SoniNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jae Ho LoNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lesly Torres-GonzalezNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sandra AlgazeNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Priya JayachandranNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Karam AshouriNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Alexandra WongNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Wu ZhangNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jian YuNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Lin ZhangNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-0018-3903
Benjamin A WeinbergRuesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Emil LouDivision of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota, USA.
Anthony F ShieldsDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Richard M GoldbergWest Virginia University Cancer Institute, Morgantown, West Virginia, USA.
John L MarshallRuesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Sanjay GoelRobert Wood Johnson Medical School, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Indrakant K SinghNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-3211-8471
Heinz-Josef LenzNorris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-2178-9568

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Daniel Butler Research FundDhont Family FoundationGloria Borges WunderGlo FoundationMing Hsieh Research GrantNCI NIH HHS P30 CA014089NCI NIH HHS P30CA 014089San Pedro Peninsula Cancer GuildVictoria and Philip Wilson Research Fund
6 · The paper itself

Abstract

Myeloid cell leukemia 1 (MCL-1) is a member of the B-cell lymphoma 2 protein family and has anti-apoptotic functions. Deregulation of MCL-1 has been reported in several cancers, including lung and breast cancer. In the present study, the association of MCL-1 expression with molecular features in colorectal cancer (CRC) has been highlighted. CRC samples from Caris Life Sciences (Phoenix, AZ) were analyzed using NextGen DNA sequencing, whole transcriptome sequencing, whole exome sequencing, and immunohistochemistry (IHC); and stratified based on MCL-1 expression as top quartile MCL-1

Indexed as

Biomarkers, TumorColorectal NeoplasmsMyeloid Cell Leukemia Sequence 1 ProteinAgedExome SequencingFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansLymphocytes, Tumor-InfiltratingMaleMicrosatellite InstabilityMiddle AgedMutationPrognosisTumor MicroenvironmentBiomarkers, TumorMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 Proteincolorectal cancerinfiltrationMCL‐1mutationsrectal tumorstumor microenvironment

Identifiers

PMID39740007
PMCPMC11826129

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.