ArticlePloS one2024
Comparison of age-related decline in C57BL/6J and CB6F1J male mice.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Conserved trajectories of age-related thigmotaxis across insects and mammals reveal the house cricket as a scalable model for behavioral aging.GeroScience · 2026Article
- Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies.Frontiers in behavioral neuroscience · 2026Article
- Morphological features of the domestic house cricket (Acheta domesticus) for translational aging studies.GeroScience · 2025Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Longitudinal Decline of Exercise Capacity in Male and Female Mice.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
3 authors.
Funding
Abstract
Variability in physical resilience to aging prompts a comprehensive examination of underlying mechanisms across organs and individuals. We conducted a detailed exploration of behavioral and physiological differences between male C57BL/6J and male CB6F1J mice across various age groups (4, 12, 20, 24 months). In behavioral assays, C57BL/6J mice displayed superior performance in rotarod tasks but higher anxiety while CB6F1J mice exhibited a decline in short-term memory with age. Grip strength, long-term memory, and voluntary wheel running declined similarly with age in both strains. Examining physiological phenotypes, C57BL/6J mice exhibited lower body fat percentages across ages compared to CB6F1J mice, though cataract severity worsened with age in both strains. Analysis of cardiac functions revealed differences between strains, with worsening left ventricular hypertrophy and structural heart abnormalities with age in CB6F1J mice along with higher blood pressure than C57BL/6J. Lesion scores showed an age-related increase in heart, kidney, and liver lesions in both strains, while lung lesions worsened with age only in CB6F1J mice. This study underscores the validity of behavioral assays and geropathology assessment in reflecting age-related decline and emphasizes the importance of considering strain specificity when using mouse models to study human aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.