ArticleProceedings of the National Academy of Sciences of the United States of America2025
Evolution takes multiple paths to evolvability when facing environmental change.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Deconstructing empirical fitness seascapes across scales of granularity.G3 (Bethesda, Md.) · 2026Article
- Deconstructing empirical fitness seascapes across scales of granularity.bioRxiv : the preprint server for biology · 2026Article
- Historical contingency limits adaptive diversification in a spatially structured environment.Evolution letters · 2026Article
- The variability of evolvability: Properties of dynamic fitness landscapes determine how phenotypic variability evolves.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evolution takes multiple paths to evolvability when facing environmental change.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adaptive laboratory evolution enhances cell yield and lipid production ofFrontiers in microbiology · 2025Article
- The evolution of human-type consciousness - a by-product of mammalian innovation mechanism - a preliminary hypothesis.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Life at all scales is surprisingly effective at exploiting new opportunities, as demonstrated by the rapid emergence of antimicrobial resistance and novel pathogens. How populations acquire this level of evolvability and the various ways it aids survival are major open questions with direct implications for human health. Here, we use digital evolution to show that changing environments facilitate the simultaneous evolution of high mutation rates and a distribution of mutational effects skewed toward beneficial phenotypes. The evolved mutational neighborhoods allow rapid adaptation to previously encountered environments, whereas higher mutation rates aid adaptation to completely new environmental conditions. By precisely tracking evolving lineages and the phenotypes of their mutants, we show that evolving populations localize on phenotypic boundaries between distinct regions of genotype space. Our results demonstrate how evolution shapes multiple determinants of evolvability concurrently, fine-tuning a population's adaptive responses to unpredictable or recurrent environmental shifts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.