Evidence map›Paper›PMID 39739808›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Molecular basis of hemoglobin binding and heme removal in

Brendan J Mahoney, Lindsey R Lyman, Jordan Ford, Jess Soule, Nicole A Cheung, Andrew K Goring, Kat Ellis-Guardiola, Michael J Collazo, Duilio Cascio, Hung Ton-That and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. 'Intelligent' proteins.Cellular and molecular life sciences : CMLS · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brendan J MahoneyDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0003-4323-9276
Lindsey R LymanLaboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20903.
Jordan FordDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0001-9501-551X
Jess SouleDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0002-6159-4354
Nicole A CheungUniversity of California, Los Angeles-United States Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095.
Andrew K GoringDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0003-4220-6472
Kat Ellis-GuardiolaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0001-7966-1052
Michael J CollazoUniversity of California, Los Angeles-United States Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095.
Duilio CascioUniversity of California, Los Angeles-United States Department of Energy Institute of Genomics and Proteomics, University of California, Los Angeles, CA 90095.ORCID 0000-0001-8285-754X
Hung Ton-ThatMolecular Biology Institute, University of California, Los Angeles, CA 90095.ORCID 0000-0003-1611-0469
Michael P SchmittLaboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20903.
Robert T ClubbDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0001-5718-3985

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Post-translocational protein folding in Gram-positive bacteriaR01DE025015 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TON-THAT, HUNG · 2015 to 2024
$3.9M
Molecular basis of heme scavenging by Gram-positive bacteriaR01AI161828 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Thompson Clubb · 2021 to 2026
$3.0M
Chemistry Biology Interface Training ProgramT32GM136614 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Patrick G. Harran · 2020 to 2026
$2.8M
UCLA Dentist-Scientist and Oral Health-Researcher Training ProgramT90DE030860 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TON-THAT, HUNG, WONG, DAVID T · 2021 to 2025
$2.1M
800 MHz NMR Console and Cryoprobe ReplacementS10OD025073 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEIGON, JULI · 2018 to 2018
$1.1M
Bruker Avance III Console and QCI Cryoprobe for a 600 MHz NMR SpectrometerS10OD016336 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLUBB, ROBERT THOMPSON · 2014 to 2014
$600k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI161828HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) DE025015HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) T90DE030860NIAID NIH HHS R01 AI161828NIAID NIH HHS T32 AI007323NIDCR NIH HHS R01 DE025015NIDCR NIH HHS T90 DE030860NIGMS NIH HHS P30 GM124165NIGMS NIH HHS T32 GM136614NIGMS NIH HHS T32 GM145388NIH HHS S10 OD016336NIH HHS S10 OD025073
6 · The paper itself

Abstract

To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin.

Indexed as

Bacterial ProteinsCorynebacterium diphtheriaeHemeHemoglobinsIronCarrier ProteinsCrystallography, X-RayHumansModels, MolecularProtein BindingBacterial ProteinsCarrier ProteinsHemehemoglobin-binding protein, bacteriaHemoglobinsIronbacterial growthheme capturehemoglobinNMRX-ray crystallography

Identifiers

PMID39739808
PMCPMC11725911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.