Evidence map›Paper›PMID 39739796›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons.

Tyler D Alexander, Stephen Tymanskyj, Kyle J Kennedy, Leonard K Kaczmarek, Manuel Covarrubias

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tyler D AlexanderDepartment of Neuroscience, Farber Institute for Neuroscience and Jefferson Synaptic Biology Center, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
Stephen TymanskyjDepartment of Neuroscience, Farber Institute for Neuroscience and Jefferson Synaptic Biology Center, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA 19107.
Kyle J KennedyDepartment of Neuroscience, Farber Institute for Neuroscience and Jefferson Synaptic Biology Center, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0009-0000-5049-3913
Leonard K KaczmarekDepartment of Pharmacology, Yale School of Medicine, Yale University, New Haven, CT 06510.ORCID 0000-0001-5128-6326
Manuel CovarrubiasDepartment of Neuroscience, Farber Institute for Neuroscience and Jefferson Synaptic Biology Center, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-0881-4143

Funding

EXPRESSION OF ION CHANNELS IN THE AUDITORY SYSTEMR01DC001919 · NIDCD · YALE UNIVERSITY · PI KACZMAREK, LEONARD K · 1993 to 2025
$9.7M
Exploring the EphB2-NMDA receptor interaction in spinal cord injury-induced neuropathic painR01NS110385 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI MANUEL L COVARRUBIAS, Matthew B Dalva · 2018 to 2026
$4.4M
Targeting visceral pain through intestinal neuropod cell GUCY2C signalingR01DK138834 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI MANUEL L COVARRUBIAS, Scott A. Waldman · 2023 to 2026
$3.4M
HHS | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01 DC01919NIDCD NIH HHS R01 DC001919NIDDK NIH HHS R01 DK138834NINDS NIH HHS R01 NS110385
6 · The paper itself

Abstract

Use-dependent spike broadening (UDSB) results from inactivation of the voltage-gated K

Indexed as

Action PotentialsGanglia, SpinalNeuronsAnimalsNeuronal PlasticityPhosphorylationRatsRats, Sprague-DawleyShaw Potassium ChannelsShaw Potassium Channelsaction potential modulationDRG neurondynamic-clampKv3 channelpain signaling

Identifiers

PMID39739796
PMCPMC11725888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.