ArticleProceedings of the National Academy of Sciences of the United States of America2025
Memory control deficits in the sleep-deprived human brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- REM sleep reduction leads to fear overgeneralization via negatively modulating prefrontal theta oscillations.BMC medicine · 2025Trial
- Sleep quality and psychological resilience: a cross-sectional study of community-dwelling adults in China.BMJ open · 2026Article
- Effects of sleep quality on the offline storage state of visual working memory.BMC psychology · 2026Article
- Sleep deprivation and memory: A neurobiological perspective.IBRO neuroscience reports · 2026Article
- Imperatorin restores behavioral and recognition memory deficits induced by REM sleep deprivation in male rats.Scientific reports · 2026Article
- Assessing relationships between cognition, sleep, and mental health in pediatric patients with chronic pain.The journal of pain · 2026Observational
- Sleep longer, think sharper: extra sleep offsets poor sleep quality in young-old adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Memory control deficits in the sleep-deprived human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought. We conclude that sleep deprivation gives rise to intrusive memories via the disruption of neural circuits governing mnemonic inhibitory control, which may rely on REM sleep.
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Registered trials
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