Observational studyPloS one2024
The effect of different anesthetics on the incidence of AKI and AKD after neurosurgical procedures.
Observational study in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Epidemiological investigation and risk factor analysis of acute kidney injury in non-intensive care unit hospitalized patients following neurosurgery.Frontiers in neurology · 2026Article
- Article
- Effect of sevoflurane-based or propofol-based anesthesia on acute kidney injury after surgery for gastric cancer: a retrospective propensity score-matched analysis.BMC anesthesiology · 2025Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) incidence after neurosurgical operations has been reported as 10-14%. The literature regarding the incidence of nosocomial acute kidney disease (AKD) following neurosurgery is scarce. This retrospective, single-center, observational study aimed to assess the impact of different anaesthetics on development of postoperative AKI and persistent AKD in neurosurgical patients. We have categorized patients depending by the type of total intravenous anaestesia with propofol or sevoflurane. Most patients (74%) were on total intravenous anesthesia with propofol, while the rest (26%) were on sevoflurane. Patients were divided into subgroups with and without AKD depending on glomerular filtration rate <or> 60 ml/min regarding kidney function at the end of intensive care unit stay. AKI was diagnosed in 341 (5.39%) patients. Significantly higher number of patients developed AKD in the sevoflurane group (16.9% vs. 6.3%). There was a significantly higher number of patients with both high and low AKI stages on sevoflurane and with hypotension during operation. Anaesthesia with sevoflurane had increased OR of 5.09 and ROC value of 0.681 for development of AKI. Anesthesia with sevoflurane had an increased OR of 4.98 and ROC value of 0.781 for development of AKD. Mortality was independently associated with anesthesia with sevoflurane, AKI development, hypotension during operation and AKD. Anesthesia with sevoflurane, hypotension during operation, and the development of AKD at the end of ICU stay were associated with higher mortality in the whole group (HR 6.996, HR 1.924 and HR 4.969, respectively). Patients treated with balanced anesthesia with sevoflurane had more frequent AKI and AKD with shorter survival. Renal toxicity of sevoflurane is pronounced in hypotension during operation and with a history of diabetes and coronary disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.