Evidence map›Paper›PMID 39739591›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro-Angiogenic Macrophage Polarization via Activation of the PI3K-Akt Signaling Pathway.

Qun Cui, Xiaona Zheng, Yunyang Bai, Yaru Guo, Shuo Liu, Yanhui Lu, Lulu Liu, Jia Song, Yang Liu, Boon Chin Heng and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Engineered bacteria reprogram tumor microenvironmentActa pharmaceutica Sinica. B · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qun CuiDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Xiaona ZhengDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Yunyang BaiDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Yaru GuoDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Shuo LiuDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Yanhui LuDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Lulu LiuDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Jia SongDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Yang LiuDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Boon Chin HengDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Fuping YouInstitute of Systems Biomedicine, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, 100191, P. R. China.
Mingming XuDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Xuliang DengNational Engineering Research Center of Oral Biomaterials and Digital Medical Devices, NMPA Key Laboratory for Dental Materials, Beijing Laboratory of Biomedical Materials & Beijing Key Laboratory of Digital Stomatology, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.
Xuehui ZhangDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, 100081, P. R. China.ORCID https://orcid.org/0000-0003-1016-6488

Funding

Beijing Municipal Natural Science Foundation 7222226Beijing Municipal Natural Science Foundation L242060Beijing Municipal Natural Science Foundation L244021Beijing Physician Scientist Training Project BJPSTP-2024-05Beijing Selecting and Advance Plan for Medical Science and Technology Innovation Achievements Transformation YC202301QX0137Central Government Guidance Funding for Local Science and Technology Projects in Shanxi Province YDZJSX2024D075National Key R&D Program of China 2022YFC2401803National Natural Science Foundation of China 32200658National Natural Science Foundation of China 52273258National Natural Science Foundation of China 82221003National Natural Science Foundation of China U22A20160Peking University Medicine Sailing Program for Young Scholars' Scientific & Technological Innovation BMU2024YFJHMX004Peking University School of Stomatology National Clinical Key Discipline Construction Project PKUSSNKP-T202101
6 · The paper itself

Abstract

Regulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at the micro- and nanoscale regulate the immune response and subsequent angiogenesis during bone regeneration remains to be elucidated. Here, the distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) matrix surfaces are established by altering the dimensions of ferroelectric nanofillers from 0D BaTiO

Indexed as

MacrophagesNeovascularization, PhysiologicOsteogenesisPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsBone RegenerationMiceRAW 264.7 CellsSignal TransductionSurface PropertiesTitaniumPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTitaniumangiogenesisbone regenerationheterogeneous surface potential distributionPI3K‐Akt signaling pathwaypro‐angiogenic macrophage polarization

Identifiers

PMID39739591
PMCPMC11848552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.