ArticleG3 (Bethesda, Md.)2025
First whole-genome sequence of Triatoma sanguisuga (Le Conte, 1855), vector of Chagas disease.
Article in G3 (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Genetic variability withinResearch square · 2026Article
- Chromosome-level genome assembly of Trichiurus japonicus resolves species boundaries and evolutionary history of cutlassfishes in Northwest Pacific.BMC genomics · 2026Article
- Chagas Disease in the 21st Century: Global Spread, Ecological Shifts, and Research Frontiers.Biology · 2025Review
- Limitations of current machine learning models in predicting enzymatic functions for uncharacterized proteins.G3 (Bethesda, Md.) · 2025Article
- Limitations of current machine learning models in predicting enzymatic functions for uncharacterized proteins.G3 (Bethesda, Md.) · 2025Article
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Abstract
Triatoma sanguisuga is the most widespread triatomine bug species in the United States. The species vectors the human parasite Trypanosoma cruzi, which causes Chagas disease. Vector-borne Chagas disease is rarely diagnosed in the United States, but T. sanguisuga has been implicated in a handful of cases. Despite its public health importance, little is known about the genomics or population genetics of T. sanguisuga. Here, we used long-read sequencing to assemble the first whole-genome sequence for T. sanguisuga using DNA extracted from 1 adult specimen from Delaware. The final size of the genome was 1.162 Gb with 77.7× coverage. The assembly consisted of 183 contigs with an N50 size of 94.97 kb. The Benchmarking Universal Single-Copy Ortholog complete score was 99.1%, suggesting a very complete assembly. Genome-wide GC content was 33.56%, and DNA methylation was 18.84%. The genome consists of 62.75% repetitive DNAs and 17,799 predicted coding genes. The assembled T. sanguisuga genome was very close in size and BUSCO score to that of Triatominae species T. dimidiata (1.16 Gb with 99.1% BUSCO score for T. sanguisuga vs 1.22 Gb with 98.7% BUSCO score for T. dimidiata) and slightly larger than that of T. infestans and Rhodnius prolixus (949 Mb with 90.4% BUSCO score and 706 Mb with 96.5% BUSCO score, respectively). The T. sanguisuga genome is the first North American triatomine species genome to be sequenced, allowing for deeper investigations into epidemiologically relevant aspects of triatomines in temperate climates, thus providing potential vector-borne disease management targets and strengthening public health preparedness.
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