Evidence map›Paper›PMID 39739571›Full record

ArticleACS nano2025

Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis Immunotherapy.

Min-Ren Chiang, Chin-Wei Hsu, Wan-Chi Pan, Ngoc-Tri Tran, Yu-Sheng Lee, Wen-Hsuan Chiang, Yu-Chen Liu, Ya-Wen Chen, Shih-Hwa Chiou, Shang-Hsiu Hu

Abstract read
In one paragraph

Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

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  12. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
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  18. Chemo-photothermal synergy ignites antitumor immunity via ferroptosis.Signal transduction and targeted therapy · 2026
    Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min-Ren ChiangDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.
Chin-Wei HsuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.
Wan-Chi PanDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.
Ngoc-Tri TranDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.
Yu-Sheng LeeDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.
Wen-Hsuan ChiangDepartment of Chemical Engineering, National Chung Hsing University, Taichung 402, Taiwan.ORCID 0000-0002-2022-0858
Yu-Chen Liu
Ya-Wen ChenNational Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan.
Shih-Hwa ChiouInstitute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taipei 112304, Taiwan.ORCID 0000-0002-8651-5755
Shang-Hsiu HuDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-8965-3918

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However, in the tumor environment, dendritic cells often exhibit impaired antigen presentation and adopt an immunosuppressive phenotype, which hinders their function and reduces their ability to efficiently present antigens. Here, a dual catalytic oxide nanosponge (DON) doubling as a remotely boosted catalyst and an inducer of programming DCs to program immune therapy is reported. Intravenous delivery of DON enhances tumor accumulation via the marginated target. At the tumor site, DON incorporates cerium oxide nanozyme (CeO

Indexed as

Antigens, NeoplasmDendritic CellsImmunotherapyLung NeoplasmsAnimalsCatalysisCell Line, TumorCeriumHumansMiceMice, Inbred C57BLReactive Oxygen SpeciesAntigens, Neoplasmceric oxideCeriumReactive Oxygen Speciesantigen captureimmunotherapylung metastasisnanozymesT cell infiltration

Identifiers

PMID39739571
PMCPMC11760334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.