Insights into the Neurobiology of Behavioral Inhibition from Nonhuman Primate Models.

Lillian J Campos, Carly M Drzewiecki, Andrew S Fox

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In one paragraph

Review in Current topics in behavioral neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Lillian J CamposDepartment of Psychology, University of California, Davis, CA, USA.

Carly M DrzewieckiCalifornia National Primate Research Center, University of California, Davis, CA, USA.

Andrew S FoxDepartment of Psychology, University of California, Davis, CA, USA. dfox@ucdavis.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with extreme behavioral inhibition (BI) are at a significantly greater risk to develop anxiety disorders later in life. We and others have identified similar early-life temperamental BI in nonhuman primates (NHPs), including rhesus monkeys. NHP models of BI provide a unique opportunity to study the neurobiology of BI in a species that shares biological, developmental, and socioemotional similarities with humans. Rhesus monkey models have identified a distributed brain circuit that includes the central extended amygdala (EAc) as being critical for the genesis of BI. By leveraging multimodal neuroimaging, brain lesions, RNA-sequencing, and viral vector manipulations in rhesus monkeys, these studies have identified specific brain regions, genetic factors, and molecular mechanisms that causally contribute to BI. Here, we discuss these findings from NHPs and how they fit into a translational framework that can contribute to our understanding of the neural circuits that give rise to the risk to develop anxiety and depressive disorders.

Indexed as

Behavior, AnimalBrainInhibition, PsychologicalAnimalsDisease Models, AnimalHumansMacaca mulattaAmygdalaAnxietyAnxious temperamentBed nucleus of stria terminalisBNSTBSTCeDevelopmentDTIExtended amygdalaFreezingHeritabilityMacaqueMRINeuroimagingPETThreatViral vectors

Identifiers

PMID39739174

DOI10.1523/JNEUROSCI.0333-16.2016

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.