SynthesisEuropean journal of pediatrics2024
The impact of exposure to phthalates in thyroid function of children and adolescents: a systematic review.
Synthesis in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Multi-omics, machine learning, and molecular simulation identify CD44 as a candidate target in endocrine-disrupting chemical-associated thyroid cancer progression.Molecular diversity · 2026Article
- Prenatal and childhood exposure to common plasticizers in relation to emotional and behavioral development through adolescence.The Science of the total environment · 2026Article
- Thyroid/parathyroid function and fluoride: role of mitochondrial DNA and SOD genetic variations.Journal of endocrinological investigation · 2026Article
- Review
- Exposure profiles to Benzophenones and their impacts on thyroid hormones in pregnant women.Journal of endocrinological investigation · 2025Article
- Emerging contaminants in the Mediterranean Sea endangering Lebanon's Palm Islands Natural Reserve.RSC advances · 2025Article
- Phthalates and epigenetics: An emerging public health concern.Current research in toxicology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phthalic acid esters, or phthalates, are plasticizers commonly used in the plastics industry and they are known for their endocrine-disrupting effects. Numerous epidemiological studies have been conducted to evaluate the effects of phthalate exposure on thyroid function, both in adults and children. However, there is still considerable debate surrounding this issue. Therefore, a systematic review was conducted to clarify existing evidence and offer new insights into the magnitude of this disruption and its potential consequences for children and adolescents' health. A comprehensive literature search using MEDLINE, Scopus, and Web of Science databases was performed. The inclusion criteria for the studies were the determination of regression coefficients between phthalates concentrations and thyroid levels, in children and adolescents. The quality assessment of the included studies was performed using the Newcastle Ottawa Scale for longitudinal studies and the Critical Appraisal Checklist for Analytical Cross-Sectional Studies scale for cross-sectional studies. Seventeen studies were included in this review, involving a total of 5616 participants, with similar phthalate levels across the diverse studies. Significant positive correlations between T3 (total and free) levels and phthalate exposure were found, as well as persistent negative associations between total-T4 levels and phthalate exposure. On the contrary, associations found regarding TSH and free-T4 did not show a consistent pattern. Conclusion: This review gathered enough evidence to conclude that exposure to phthalates causes an increase in T3 (total and free) levels and a decrease in total-T4 levels, which is consistent with previous animal studies. These findings highlight the importance of minimizing contact with plasticizers and microplastics in the environment, guaranteeing the safety of food products for the health of children and adolescents.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.