Evidence map›Paper›PMID 39739049›Full record

ArticleClinical oral investigations2024

Constructing two bifunctional tooth-targeting antimicrobial peptides for caries management: an in vitro study.

Pei Hu, Pan Chen, Gengyu Zhou, Jingyu Hu, Surong Chen, Yingjie Li, Yan Yang, Jingzhi Ma

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pei HuDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Pan ChenDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Gengyu ZhouDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Jingyu HuDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Surong ChenDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Yingjie LiDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China.
Yan YangDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China. yangyantj@hust.edu.cn.
Jingzhi MaDepartment of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, Wuhan, Hubei Province, 430030, China. majingzhi@hust.edu.cn.

Funding

National Natural Science Foundation of China 81700961National Natural Science Foundation of China 81873714Natural Science Foundation of Hubei Province 2024AFB607
6 · The paper itself

Abstract

objectivesCaries is a significant public health challenge. Herein, novel tooth-targeting antimicrobial peptides (HABPs@AMPs) were developed by combining the antimicrobial peptide DJK-5 with hydroxyapatite (HA) binding peptides, providing a potential new strategy for caries management. MATERIALS AND

methodsThe minimal inhibitory concentration (MIC

resultsThe best performing peptides, DJK-5@SVA and SVA@DJK-5 exhibited MIC

conclusionsDJK-5@SVA with good affinity for HA, has excellent biocompatibility and efficacy against S. mutans biofilms. CLINICAL RELEVANCE: HABPs@AMPs with effective inhibitory effects on the growth of S. mutans and biofilm formation, contributing to intraoral targeted application AMPs and providing a new strategy for caries management.

Indexed as

Antimicrobial PeptidesBiofilmsDental CariesDurapatiteMicrobial Sensitivity TestsMicroscopy, ConfocalStreptococcus mutansAntimicrobial Cationic PeptidesHumansIn Vitro TechniquesOligopeptidesAntimicrobial Cationic PeptidesAntimicrobial PeptidesDJK-5 peptideDurapatiteOligopeptidesAntimicrobial peptidesBiofilmsDental cariesDJK-5 peptideHydroxyapatite-binding peptide

Identifiers

PMID39739049

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.