Evidence map›Paper›PMID 39739040›Full record

ArticleEuropean radiology2025

Separating dementia with Lewy bodies from Alzheimer's disease dementia using a volumetric MRI classifier.

Aniek M van Gils, Antti J Tolonen, Hanneke F M Rhodius-Meester, Patrizia Mecocci, Ritva Vanninen, Kristian Steen Frederiksen, Frederik Barkhof, Bas Jasperse, Jyrki Lötjönen, Wiesje M van der Flier and 2 more

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Aniek M van Gils *Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Antti J Tolonen *Combinostics Ltd, Tampere, Finland. antti.tolonen@combinostics.com.ORCID http://orcid.org/0000-0002-4763-9747
Hanneke F M Rhodius-MeesterAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Patrizia MecocciDivision of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Ritva VanninenInstitute of Clinical Medicine/Radiology, University of Eastern Finland, Kuopio, Finland.
Kristian Steen FrederiksenDanish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Frederik BarkhofDepartment of Radiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Bas JasperseDepartment of Radiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Jyrki LötjönenCombinostics Ltd, Tampere, Finland.
Wiesje M van der FlierAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Afina W LemstraAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Alzheimer’s Disease Neuroimaging Initiative

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDistinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) dementia, particularly in patients with DLB and concomitant AD pathology (DLB/AD+), can be challenging and there is no specific MRI signature for DLB. The aim of this study is to examine the additional value of MRI-based brain volumetry in separating patients with DLB (AD+/-) from patients with AD and controls.

methodsWe included 1518 participants from four cohorts (ADC, ADNI, PDBP and PredictND); 147 were patients with DLB (n = 76, DLB/AD+; n = 71, DLB/AD-), 668 patients with AD dementia, and 703 controls. We used an automatic segmentation tool to compute volumes of 70 brain regions, for which age, sex, and head size-dependent z-scores were calculated. We compared individual regions between the diagnostic groups and evaluated whether combining multiple regions improves differentiation. To assess the diagnostic performance, we used the area under the receiver operating characteristic curve (AUC) and sensitivity.

resultsThe classifier using the combination of 70 volumetric brain regions correctly classified 60% of patients with DLB and 70% of patients with AD dementia. For DLB vs. AD, the classifier produced an AUC of 0.80 (0.77-0.83), which outperformed the best individual region, hippocampus (AUC: 0.73 [0.69-0.76], p < 0.01). For the comparison of DLB/AD+ vs. AD, the classifier increased the AUC to 0.74 (0.68-0.80), which was 0.70 (0.64-0.76) for the hippocampus, p = 0.25.

conclusionUsing a combination of volumetric brain regions improved the classification accuracy, and thus the discrimination, of patients with DLB with and without concomitant AD pathology and AD. KEY POINTS: Question No specific MRI signature for dementia with Lewy bodies (DLB) exists, making the differential diagnosis challenging, especially with dementia due to Alzheimer's disease (AD). Findings Volumes of individual brain regions defined by automatic MRI segmentation differed between DLB and AD patients and controls. Clinical relevance Automatic MRI segmentation can contribute to improving the discrimination of patients with DLB and AD, especially in non-specialized memory clinics.

Indexed as

Alzheimer DiseaseBrainLewy Body DiseaseMagnetic Resonance ImagingAgedAged, 80 and overDiagnosis, DifferentialFemaleHumansMaleOrgan SizeSensitivity and SpecificityAutomated quantificationBrainDementia with Lewy bodiesMRI

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PMID39739040

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