Evidence map›Paper›PMID 39739003›Full record

ArticleScientific reports2024

Plasma fibrinogen as a potential biomarker of cognitive impairment after acute ischemic stroke.

Chunxiao Wei, Weijie Zhai, Panpan Zhao, Li Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunxiao WeiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Weijie ZhaiDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Panpan ZhaoDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.
Li SunDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China. sunli99@jlu.edu.cn.

Funding

General Program of the National Natural Science Foundation of China No. 82071442Jilin Provincial Department of Finance JLSWSRCZX2021-004
6 · The paper itself

Abstract

Fibrinogen (FBG) has been discovered to be associated with cognitive impairment (CI) and dementia. However, the exact correlation between FBG levels and CI after acute ischemic stroke (AIS) remains uncertain. Plasma FBG levels were measured in 398 patients with AIS who underwent comprehensive neuropsychological evaluation. To assess the correlation of FBG with global cognitive function, physical status, anxiety, depression, and psychiatric symptoms. Multifactorial logistic regression was used to analyze risk factors for CI. Constructed and plotted a nomogram graph to visualize the CI prediction model. The model was further evaluated for discrimination, calibration, and clinical utility. The results indicate that plasma FBG levels are significantly elevated in patients with CI compared to those with non-cognitive impairment (NCI). Analysis of the overall population reveals that elevated FBG levels are correlated with both reduced cognitive function and decreased activity status. After adjusting for other influencing factors, high FBG levels were identified as a risk factor for the incidence of CI. We developed an intuitive and valid predictive model for CI, demonstrating its suitability for clinical application. In conclusion, our study demonstrates that plasma FBG serves as a potential biomarker of CI following AIS, offering a novel perspective for the identification of CI.

Indexed as

BiomarkersCognitive DysfunctionFibrinogenIschemic StrokeAgedAged, 80 and overFemaleHumansMaleMiddle AgedRisk FactorsBiomarkersFibrinogenAcute ischemic strokeCognitive impairmentDementiaFibrinogen

Identifiers

PMID39739003
PMCPMC11685652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.