Evidence map›Paper›PMID 39738915›Full record

ArticleTransgenic research2024

Transgenic overexpression of UDP glycosyltransferase gene UGT41A3 induces resistance to nucleopolyhedrovirus in Bombyx mori.

Chunying Gong, Junwen Ai, Yong Liu, Xingjian He, Hong Xue, Chaohua Jia, Zhuohua Chen, Hanfu Xu, Rongpeng Liu, Yong Yang

Abstract read
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In one paragraph

Article in Transgenic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chunying GongThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.
Junwen AiThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China. aijunwen718@sina.com.
Yong LiuThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.
Xingjian HeThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.
Hong XueThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.
Chaohua JiaThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.
Zhuohua ChenThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.
Hanfu XuState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400715, China.
Rongpeng LiuState Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing, 400715, China.
Yong YangThe Sericultural Research Institute of Hunan Province, Changsha, 410127, Hunan, China.

Funding

the China Agriculture Research System CARS-18the Key R&D Program of Hunan Province 2021NK2011the Natural Science Foundation of Hunan Province 2021JJ30383
6 · The paper itself

Abstract

Bombyx mori nuclear polyhedrosis, caused by B. mori nucleopolyhedrovirus (BmNPV), threatens sericulture seriously. To explore strategies for controlling it, the UDP glycosyltransferase gene UGT41A3 (BmUGT41A3) was targeted. UGT is involved in exogenous substances detoxification and endogenous biomass regulation in insects. Early embryos of the BmNPV-sensitive variety 'HYB' were used to obtain the transgenic line HYB-UGT41A3, overexpressing BmUGT41A3 under the IE1 promoter. qPCR results revealed that, compared with the wild-type control 'HYB', BmUGT41A3 was upregulated during the individual developmental stages of HYB-UGT41A3 from silkworm eggs to fifth-instar larvae; peak expression was observed in the third-instar larvae, which presented the most significantly upregulated expression. Individual-tissues qPCR results revealed that BmUGT41A3 expression was highest in the hemocytes of HYB-UGT41A3, followed by the midgut, whereas expression in HYB was very low. Gradient feeding of BmNPV on HYB-UGT41A3 and control 'HYB' larvae on the first day of the second-instar stage. The results revealed that the LC

Indexed as

Animals, Genetically ModifiedBombyxLarvaNucleopolyhedrovirusesAnimalsDisease ResistanceGlycosyltransferasesInsect ProteinsGlycosyltransferasesInsect ProteinsBmNPVBombyx mori nuclear polyhedrosisDisease resistanceTransgenic overexpressionUDP glycosyltransferase gene UGT41A3

Identifiers

PMID39738915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.