ArticleAnnals of surgical oncology2025
Recurrence Patterns and Long-Term Results After Curative Surgery for Patients With Breast Cancer.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Thermal ablation for early-stage breast cancer: cryoablation, microwave ablation, radiofrequency ablation, high-intensity focused ultrasound ablation, and laser ablation - a systematic review.Breast (Edinburgh, Scotland) · 2026Pooled it
- Invited Editorial About "Tumor Spread Through Air Spaces as a Predictor of Survival in Resected Pulmonary Lymphoepithelial Carcinoma" by Chen et al: Introducing the First Pathologic Grading System for PLEC.Annals of surgical oncology · 2025Article
- Tri-modality Therapy in Esophageal Carcinoma is at a Crossroad.Annals of surgical oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current study aimed to examine second breast cancer (SBC) risks associated with breast-conserving surgery (BCS) and unilateral mastectomy among breast cancer (BC) survivors.
methodsThe study enrolled patients with diagnoses of stages I to III BC who underwent surgery between 2000 and 2019. Fine-Gray competing risk regression models were used to estimate the cumulative incidence of SBC and to evaluate the associations between clinical factors and SBC development. Poisson regression analysis was performed to assess the risk for SBC after BCS compared with mastectomy by age and latency period. The Kaplan-Meier method was applied to examine survival between patients undergoing breast-conserving therapy (BCT) and those undergoing mastectomy for SBC.
resultsAmong 740,349 patients, 467,480 underwent BCS, and 272,869 underwent mastectomy. The 10-year cumulative incidence of mastectomy was 3.77% for SBC and 2.11% for BCS. Compared with mastectomy, BCS was associated with a significantly higher risk of LR and a modestly elevated risk of contralateral breast cancer (CBC). The significant risk factors for SBC were age at initial BC diagnosis, race, marital status, year of diagnosis, tumor size, histology, molecular subtype, cancer stage, metropolitan status, type of surgery, and radiotherapy. Dynamic risk assessments showed that the relative risk of SBC after BCS versus mastectomy decreased with advancing age, but increased with longer follow-up periods.
conclusionsThis cohort study showed that BC survivors undergoing BCS have a higher risk of SBC than those undergoing mastectomy. With the ongoing evolution of surgical options, achieving optimal long-term outcomes necessitates a more comprehensive assessment that balances oncologic efficacy with patient-centered outcomes.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.